THE EFFECT OF FASTING ON PLASMA GLUCOSE LEVEL IN DIABETIC MALE RATS INDUCED BY STREPTOZOCINE

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KHODAEI N.; PARVIZI M.R.; POURHEYDARI GH.R.; GHORBANI MAHDI

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Journal: Annals of Military and Health Sciences Research Year:2007 | Volume:5 | Issue:3 (SERIAL NUMBER 19) Page(s): 1355-1358

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Title

THE EFFECT OF FASTING ON PLASMA GLUCOSE LEVEL IN DIABETIC MALE RATS INDUCED BY STREPTOZOCINE

Author(s)

KHODAEI N. | PARVIZI M.R. | POURHEYDARI GH.R. | GHORBANI MAHDI | Issue Writer Certificate

Keywords

STREPTOZOCINEQ3

TYPE-I DIABETESQ3

HYPOGLYCEMIAQ3

RATQ3

FASTINGQ3

Abstract

Background: HYPOGLYCEMIA is the most common complication of TYPE-I DIABETES. In diabetic patients, the common cause of HYPOGLYCEMIA is absolute or relative increase in plasma insulin level. Sometimes overnight FASTING or emission of one meal decrease blood glucose. But FASTING-induced HYPOGLYCEMIA in TYPE-I DIABETES without insulin consumption has been not reported yet. The aim of this study is the effects of FASTING on blood glucose in type-I diabetic RATs.Materials and methods: 16 male wistar RATs with average weight 250±25 grams were used in this study. The RATs were divided into control and diabetic groups. RATs were diabetized by IP injection of STREPTOZOCINE (60 mg/kg). All RATs were fasted for 24 hours. During FASTING, the blood glucose was measured for interval of 3 hours.Results: In diabetic groups, blood glucose decreased from 546mg/kg at the bigining to 24mg/kg at the end of experiment and blood glucose in control groups, declined from 92mg/kg to 52mg/kg after 24 hours.However the most slope reduction of FBS in both groups was obtained six hours after FASTING.Conclusion: It seems the prolonged FASTING in type-I diabetic RATs produces sever HYPOGLYCEMIA (after 6-9 hours) even without insulin consumption. Hence diabetic patients can not undergo prolonged FASTING more than 6 hours and achieve HYPOGLYCEMIA.

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APA: Copy

KHODAEI, N., PARVIZI, M.R., POURHEYDARI, GH.R., & GHORBANI, MAHDI. (2007). THE EFFECT OF FASTING ON PLASMA GLUCOSE LEVEL IN DIABETIC MALE RATS INDUCED BY STREPTOZOCINE. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 5(3 (SERIAL NUMBER 19)), 1355-1358. SID. https://sid.ir/paper/96562/en

Vancouver: Copy

KHODAEI N., PARVIZI M.R., POURHEYDARI GH.R., GHORBANI MAHDI. THE EFFECT OF FASTING ON PLASMA GLUCOSE LEVEL IN DIABETIC MALE RATS INDUCED BY STREPTOZOCINE. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2007;5(3 (SERIAL NUMBER 19)):1355-1358. Available from: https://sid.ir/paper/96562/en

IEEE: Copy

N. KHODAEI, M.R. PARVIZI, GH.R. POURHEYDARI, and MAHDI GHORBANI, “THE EFFECT OF FASTING ON PLASMA GLUCOSE LEVEL IN DIABETIC MALE RATS INDUCED BY STREPTOZOCINE,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 5, no. 3 (SERIAL NUMBER 19), pp. 1355–1358, 2007, [Online]. Available: https://sid.ir/paper/96562/en

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