DIFFERENTIATION OF HUMAN OVARIAN FOLLICULAR GRANULOSA CELLS INTO KERATINOCYTES

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MALEKI MASOUD; Ghoreishi Seyed Amin; Dezfulian Mahruz; ABDOLMALEKI ARASH

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Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2021 | Volume:31 | Issue:11 Page(s): 813-822

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Title

DIFFERENTIATION OF HUMAN OVARIAN FOLLICULAR GRANULOSA CELLS INTO KERATINOCYTES

Author(s)

MALEKI MASOUD | Ghoreishi Seyed Amin | Dezfulian Mahruz | ABDOLMALEKI ARASH | Issue Writer Certificate

Keywords

Keratinocyte

Western blotting

Flow cytometry

Keratin10

Keratin14

Granulosa cells

Abstract

Background & Aims: Stem cells are undifferentiated cells and are found in different tissues. These cells have capacity of self-renewal and differentiation into other lineages. Granulosa cells (GCs) are the multipotent stem cells. In the present research we evaluated the differentiation potential of GCs into Keratinocytes. Material & Methods: GCs were cultured after enzymatic isolation from ovarian follicle. Then, Keratinocyte inductive medium was added and expression of Keratin10 and Keratin14 were investigated with Western blotting technique. Results: The results of the flow cytometric analysis of the isolated cells indicated the high expression of mesenchymal stem cell specific antigens (p < 0. 05). Also, the results of the Western blotting showed the expression of creatine 10 and creatine 14 proteins in all groups except for negative control (p< 0. 05). Conclusion: Human Granulosa cells have a very high ability to differentiate into keratinocytic cells, and with further research, it is possible to provide a suitable substrate for the use of human Granulosa cells to treat severe skin lesions.

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APA: Copy

MALEKI, MASOUD, Ghoreishi, Seyed Amin, Dezfulian, Mahruz, & ABDOLMALEKI, ARASH. (2021). DIFFERENTIATION OF HUMAN OVARIAN FOLLICULAR GRANULOSA CELLS INTO KERATINOCYTES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 31(11 ), 813-822. SID. https://sid.ir/paper/965645/en

Vancouver: Copy

MALEKI MASOUD, Ghoreishi Seyed Amin, Dezfulian Mahruz, ABDOLMALEKI ARASH. DIFFERENTIATION OF HUMAN OVARIAN FOLLICULAR GRANULOSA CELLS INTO KERATINOCYTES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2021;31(11 ):813-822. Available from: https://sid.ir/paper/965645/en

IEEE: Copy

MASOUD MALEKI, Seyed Amin Ghoreishi, Mahruz Dezfulian, and ARASH ABDOLMALEKI, “DIFFERENTIATION OF HUMAN OVARIAN FOLLICULAR GRANULOSA CELLS INTO KERATINOCYTES,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 31, no. 11 , pp. 813–822, 2021, [Online]. Available: https://sid.ir/paper/965645/en

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