ANTIBIOTIC EFFLUX PUMPS

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NAJAR PIRAYEH SH.; ESMAEILI DAVOUD

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Journal: Annals of Military and Health Sciences Research Year:2004 | Volume:2 | Issue:1 (Serial Number 5) Page(s): 301-306

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Information Journal Paper

Title

ANTIBIOTIC EFFLUX PUMPS

Author(s)

NAJAR PIRAYEH SH. | ESMAEILI DAVOUD | Issue Writer Certificate

Keywords

EFFLUX PUMPSQ4

MICROORGANISMSQ4

MULTIDRUG RESISTACEQ3

RESISTANCE MECHANISMQ4

Abstract

Background: Efflux is the process in which bacteria transport compounds outside the cell which are potentially toxic, such as drug or chemicals or compounds. Materials and methods: For this review article by using key words: multidrug resistance, microorganims, EFFLUX PUMPS, RESISTANCE MECHANISM we have assessed 12 articles in journals published during 1997-2002 Results: Multidrug efflux systems endow on bacterial cells the ability to limit the access of antimicrobial agents to their targets. By actively pumping out antibiotic molecules, these systems prevent the intra cellular accumulation necessary for antibiotics to exert their lethal actively. Drug efflux appears to be one of the most widespread antibiotic RESISTANCE MECHANISMs among MICROORGANISMS, since it has been demonstrated to occur in many Gram positive and Gram-negative bateria including medically important species like staphylococci, streptococci, enterobacteria and opportunistic pathogens like pseudomonas aeruginosa. Bacterial antimicrobial efflux transporters have generally been grouped into five superfamily. These include the major facilitator superfamily (MFS), the ATP- binding cassette family, the resistance- nodulation- division (RND) family, the small multidrug resistance (SMR) and multidrug and toxic compound extrusion (MATE) family. Conclusion: EFFLUX PUMPS can be specific for only one substrate or accommodate a more or less wide range of noxious products.

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APA: Copy

NAJAR PIRAYEH, SH., & ESMAEILI, DAVOUD. (2004). ANTIBIOTIC EFFLUX PUMPS. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 2(1 (Serial Number 5)), 301-306. SID. https://sid.ir/paper/96625/en

Vancouver: Copy

NAJAR PIRAYEH SH., ESMAEILI DAVOUD. ANTIBIOTIC EFFLUX PUMPS. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2004;2(1 (Serial Number 5)):301-306. Available from: https://sid.ir/paper/96625/en

IEEE: Copy

SH. NAJAR PIRAYEH, and DAVOUD ESMAEILI, “ANTIBIOTIC EFFLUX PUMPS,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 2, no. 1 (Serial Number 5), pp. 301–306, 2004, [Online]. Available: https://sid.ir/paper/96625/en

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