NADPH-DIAPHORASE ACTIVITY AND CB-28KD IMMUNOREACTIVITY IN SPINAL MOTONEURONS OF NEONATAL RATS AFTER A PERIPHERAL NERVE LESION

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FALAH Z.

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Journal: Annals of Military and Health Sciences Research Year:2004 | Volume:2 | Issue:1 (Serial Number 5) Page(s): 279-287

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Title

NADPH-DIAPHORASE ACTIVITY AND CB-28KD IMMUNOREACTIVITY IN SPINAL MOTONEURONS OF NEONATAL RATS AFTER A PERIPHERAL NERVE LESION

Author(s)

FALAH Z. | Issue Writer Certificate

Keywords

AXOTOMYQ4

CALBINDINQ4

MOTONEURONQ4

NADPH-DIAPHORASEQ4

Abstract

Background: Our previous studies have shown that median and ulnar nerve lesion induced CALBINDIN (CB) immunoreactivity in some injured MOTONEURONs in developing rats. MOTONEURON death induced by sciatic nerve transection in neonatal rats has been related to induction of neuronal isoform of nitric oxide synthase. The present study investigated whether CB expression is related to the death or survival of MOTONEURONs in response to AXOTOMY. Materials and methods: After median and ulnar nerve transection at P2 and Pl, NADPH-DIAPHORASE histochemistry was performed on cervical sections to analyze the induction of nitric oxide synthase in MOTONEURONs retrogradely labeled with fast blue and immunostained for CB. NADPH-DIAPHORASE reactivity was not detectable in fast blue (FB) labeled MOTONEURONes after 1 and 2weeks after nerve lesion at P2. Results: following nerve lesion at P7, some FB labeled MOTONEURONs showed enzyme activity 2 weeks after nerve lesion which were not CB immunoreactive. Conclusion: The results indicate the possible role of nitric oxide in nerve regeneration and the role of CB in neuroprotection from cell death or in mechanisms of neurodegeneration.

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APA: Copy

FALAH, Z.. (2004). NADPH-DIAPHORASE ACTIVITY AND CB-28KD IMMUNOREACTIVITY IN SPINAL MOTONEURONS OF NEONATAL RATS AFTER A PERIPHERAL NERVE LESION. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 2(1 (Serial Number 5)), 279-287. SID. https://sid.ir/paper/96628/en

Vancouver: Copy

FALAH Z.. NADPH-DIAPHORASE ACTIVITY AND CB-28KD IMMUNOREACTIVITY IN SPINAL MOTONEURONS OF NEONATAL RATS AFTER A PERIPHERAL NERVE LESION. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2004;2(1 (Serial Number 5)):279-287. Available from: https://sid.ir/paper/96628/en

IEEE: Copy

Z. FALAH, “NADPH-DIAPHORASE ACTIVITY AND CB-28KD IMMUNOREACTIVITY IN SPINAL MOTONEURONS OF NEONATAL RATS AFTER A PERIPHERAL NERVE LESION,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 2, no. 1 (Serial Number 5), pp. 279–287, 2004, [Online]. Available: https://sid.ir/paper/96628/en

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