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Information Journal Paper

Title

EFFICACY OF DIFFERENT IMMUNIZATION METHODS AGAINST LEISHMANIA PARASITE IN ORDER TO PROPHYLAXIS OF LEISHMANIASIS

Pages

  359-364

Abstract

 Background: LEISHMANIAsis is a disease with different clinical manifestation produced by the genus LEISHMANIA. Eradication of the disease has proven to be difficult. Chemotherapy has only a modest effect and there IS no effective and safe vaccine against any from of clinical LEISHMANIAsis. However, individuals who recovered naturally from infection develop strong immunity against reinfection suggesting that vaccination against LEISHMANIAsis is feasible. Materials and methods: This study is a review article and is based on more than 30 articles about PROPHYLAXIS of LEISHMANIAsis during recent five years. Results: In 2002 year several studies in different countries about LEISHMANIA major suggesting as a whole use of LACK antigen with IL-12 adjuvant mix antigens lack and MIOGE* Mix antigens lack+Lmsti 1+TSA *Mix surface antigens lmstil+TSA+Leif=Leish 111f. *Mix leish 111f + IL-12 or Leish 111f + MPA+SLA have high efficient protective immune response but the result of study in Brazil at that time about meta 1 gene is not effective. In 2003 year several studies in different country shows the use of ODN, CPG, ALM and BCG as a adjuvant and the role of dendritic cells with IL-12 in generation of protective is very important meanwhile increase of GM-CSF * antigen recombinant Histone synthesized * Role of CD4* with CD8* the effective of NF Kappaß cells in induction of Th1 * The use of two different adjuvant ODN, GPC with alive parasite and Man 5-DPPE coated liposomes to induce cellular immunity against parasite is important also. In 2003 studies about LEISHMANIA infantum shows that use of IL-18 with IL-12 * Lack + DNA P36 antigens* P80 antigen * Mix antigens GP63 + CP+LPG induced Type 1 response against parasite.      

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  • Cite

    APA: Copy

    SHAD DEL, M., OURMAZDI, H., FATEMINASAB, F., & FARAH YAR, S.. (2004). EFFICACY OF DIFFERENT IMMUNIZATION METHODS AGAINST LEISHMANIA PARASITE IN ORDER TO PROPHYLAXIS OF LEISHMANIASIS. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 2(2 (Serial Number 6)), 359-364. SID. https://sid.ir/paper/96736/en

    Vancouver: Copy

    SHAD DEL M., OURMAZDI H., FATEMINASAB F., FARAH YAR S.. EFFICACY OF DIFFERENT IMMUNIZATION METHODS AGAINST LEISHMANIA PARASITE IN ORDER TO PROPHYLAXIS OF LEISHMANIASIS. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2004;2(2 (Serial Number 6)):359-364. Available from: https://sid.ir/paper/96736/en

    IEEE: Copy

    M. SHAD DEL, H. OURMAZDI, F. FATEMINASAB, and S. FARAH YAR, “EFFICACY OF DIFFERENT IMMUNIZATION METHODS AGAINST LEISHMANIA PARASITE IN ORDER TO PROPHYLAXIS OF LEISHMANIASIS,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 2, no. 2 (Serial Number 6), pp. 359–364, 2004, [Online]. Available: https://sid.ir/paper/96736/en

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