THE EVALUATION OF HISTOPATHOLOGIC EFFECTS OF MUSTARD GAS ON TESTIS PARANCHYME IN RAT

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GHAHARI L.; SAFFARI NEZHAD M.R.; MORADI A.; MARKAZI MOGHADAM N.; DADPEY M.; SAFARI M.

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Journal: Annals of Military and Health Sciences Research Year:2004 | Volume:2 | Issue:3 (Serial Number 7) Page(s): 371-374

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Title

THE EVALUATION OF HISTOPATHOLOGIC EFFECTS OF MUSTARD GAS ON TESTIS PARANCHYME IN RAT

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Keywords

SULFUR MUSTARDQ3

TESTISQ4

RATQ3

Abstract

Background: SULFUR MUSTARD (HD) (bis(2-chloroethyl) sulfide) is a strong alkylating agent with known mutagenic and suspected carcinogenic properties. Materials &Methods: 40 Albino-Nmari male RATs, 3 months old, were divided into four groups (10 in each group) and injected with 5, 10 mg /kg SULFUR MUSTARD in tyrods buffer .After 8 weeks RATs were killed. The samples were fixed in formaldehyde solution (%10), stained with H&E and studied with light microscope. Results: Increased distance between seminiferous tubules. Accumulation of necrotic materials of the cells in the lumen of seminiferous, oligospermia, displacement of somniferous tubules and changing the situation of sertoli nuclei from the abdominal positioning to basal in both groups of SULFUR MUSTARD that compared with normal and tyrods groups. Conclusion: Presence of necrotic form of spermatocytes and necrotic cells with picnotic nuclei in both SULFUR MUSTARD groups but more in 10 mg/kg HD.

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APA: Copy

GHAHARI, L., SAFFARI NEZHAD, M.R., MORADI, A., MARKAZI MOGHADAM, N., DADPEY, M., & SAFARI, M.. (2004). THE EVALUATION OF HISTOPATHOLOGIC EFFECTS OF MUSTARD GAS ON TESTIS PARANCHYME IN RAT. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 2(3 (Serial Number 7)), 371-374. SID. https://sid.ir/paper/96858/en

Vancouver: Copy

GHAHARI L., SAFFARI NEZHAD M.R., MORADI A., MARKAZI MOGHADAM N., DADPEY M., SAFARI M.. THE EVALUATION OF HISTOPATHOLOGIC EFFECTS OF MUSTARD GAS ON TESTIS PARANCHYME IN RAT. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2004;2(3 (Serial Number 7)):371-374. Available from: https://sid.ir/paper/96858/en

IEEE: Copy

L. GHAHARI, M.R. SAFFARI NEZHAD, A. MORADI, N. MARKAZI MOGHADAM, M. DADPEY, and M. SAFARI, “THE EVALUATION OF HISTOPATHOLOGIC EFFECTS OF MUSTARD GAS ON TESTIS PARANCHYME IN RAT,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 2, no. 3 (Serial Number 7), pp. 371–374, 2004, [Online]. Available: https://sid.ir/paper/96858/en

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