Background: Renal colic is a common cause of acute severe pain. Opioids and non-opioids analgesics and NSAIDs and phosphodiesterase enzyme (PDE) inhibitors are four medical categories that recommended for treatment, but the relative efficacy of these drugs is uncertain.
Materials and Methods: To examine the benefits and disadvantages of pethidine, piralgin, diclofenac and aminophyllin for the management of pain in acute renal colic, as a randomized clinical trial study, patients with four suspected renal colic (n=200) were randomised to receive these 4-drugs at emergency ward of -hospitals. Pain relief and side effects was assessed at one hour after the analgesics. Oatas has been analised by statistical soft ware of SPSS-ver.11. .
Results: pain relieved in the pethidine group after 30 minute and one hour was %60 (30 patients ) & %94(47 patients ),for piralgin group was %54(27 patients) &%92(46 patients), diclofenac group was %28(14 patients)& %68(34 patients) and for aminophylline was %24(12 patients) &%62 (31 patients).(P< 0/05) The side-effects of 4-groups was included: pethidine: nausea (11 Patients), vomiting (7 Patients), respiratory depression(3 Patients) and headache(2 Patients) ; piralgin (3 Patients); aminophylline: orthostatic hypothension(7Patients), vertigue (9Patients ), headache( 12patients); diclofenac had no side-effect.
Conclusion: Tramadol response was as same as pethidine but less side-effects diclofenac is a good choice for mild pain; but aminophyllin had a bad response with very much side-effects..