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Information Journal Paper

Title

Clinical Trials Developed in Brazil on Covid-19: What is Being Researched?

Author(s)

 Carvalho Laureano Isla Camilla | Cabral Cavalcanti Alidianne Fabia | CAVALCANTI ALESSANDRO LEITE | Issue Writer Certificate 

Pages

  0-0

Abstract

 Background: The coronavirus disease 2019 pandemic (COVID-19) has brought great public health challenges into our lives. To date, there has been no specifi c therapeutic protocol for this disease, which requires a study with high-quality evidence. Objectives: To analyze Clinical Trials on COVID-19 in Brazil. Methods: Documentary research was conducted on the Clinical Trial registration platform. For the search strategy, the “ COVID-19” keyword was established in the “ condition or disease” section and “ Brazil” in the “ country” section. No limit on the search period was considered. Data were analyzed and presented using descriptive statistics. Results: Of the 81 registered Clinical Trials, 48 met the eligibility criteria. The sample size ranged from 10 to 3, 000 individuals. Most studies recruited individuals aged 18-64 years (48. 5%) and > 65 years (48. 5%). Regarding the study design, randomized (91. 6%), parallel (89. 5%), quadruple-blind (39. 6%), and therapeutic (97. 9%) types were more frequent. Most studies used standard two-arm trial (70. 8%), used drugs (79. 2%), placebo (58. 3%), and were sponsored by pharmaceutical/biotechnology companies and universities with 33. 3% and 29. 2%, respectively. Conclusions: Clinical Trials under development in Brazil on COVID-19 are mostly carried out with adult and elderly participants, and regarding the study design, have a predominance of randomized allocation, parallel model, quadruple-blind masking with a therapeutic purpose. Most studies use antithrombotic agents or combinations of antithrombotic agents.

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    APA: Copy

    Carvalho Laureano, Isla Camilla, Cabral Cavalcanti, Alidianne Fabia, & CAVALCANTI, ALESSANDRO LEITE. (2020). Clinical Trials Developed in Brazil on Covid-19: What is Being Researched?. SHIRAZ E MEDICAL JOURNAL, 21(12), 0-0. SID. https://sid.ir/paper/969522/en

    Vancouver: Copy

    Carvalho Laureano Isla Camilla, Cabral Cavalcanti Alidianne Fabia, CAVALCANTI ALESSANDRO LEITE. Clinical Trials Developed in Brazil on Covid-19: What is Being Researched?. SHIRAZ E MEDICAL JOURNAL[Internet]. 2020;21(12):0-0. Available from: https://sid.ir/paper/969522/en

    IEEE: Copy

    Isla Camilla Carvalho Laureano, Alidianne Fabia Cabral Cavalcanti, and ALESSANDRO LEITE CAVALCANTI, “Clinical Trials Developed in Brazil on Covid-19: What is Being Researched?,” SHIRAZ E MEDICAL JOURNAL, vol. 21, no. 12, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/969522/en

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