Effects of Resistance and Endurance Training on HIF-1 and VEGF in Heart Tissues of Pregnant Rats with Cadmium Toxicity

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Torabimehr Farzaneh; KAZEMI NASIBEH; HOSSEINI SEYED ALI

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Journal Paper

Paper Information

Journal: GENE, CELL AND TISSUE Year:2019 | Volume:6 | Issue:1 Page(s): 0-0

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Title

Effects of Resistance and Endurance Training on HIF-1 and VEGF in Heart Tissues of Pregnant Rats with Cadmium Toxicity

Author(s)

Torabimehr Farzaneh | KAZEMI NASIBEH | HOSSEINI SEYED ALI | Issue Writer Certificate

Keywords

Exercise

Cadmium

Pregnancy

HIF-1

VEGF

Abstract

Background: Exposure to cadmium can cause cardiovascular disorders, including possible risks of angiogenesis abnormalities associated with Hypoxia Inducible Factor (HIF), in pregnancy period. Objectives: This study aimed to investigate the effects of resistance and endurance training on HIF-1 and vascular endothelial growth factor (VEGF) levels in heart tissue of pregnant rats with cadmium toxicity. Methods: In this study, 48 female rats were selected and divided into 6 groups of 8 rats, including (1) cadmium, (2) resistance training, (3) resistance training with cadmium consumption, (4) endurance training, (5) endurance training with cadmium consumption, and (6) control. Groups 2, 3, 4, and 5 performed three weeks of resistance and endurance training, five sessions per week. Also, groups 1, 3, and 5 received cadmium as cadmium chloride dissolved in water as 400 mg per liter through drinking water. To analyze the data, Kolmogorov-Smirnov, One-way ANOVA, and Tukey’ s post hoc tests were used and P 0. 05 was considered statistically significant. Results: Cadmium had a significant effect on the increase of HIF1- and VEGF (P = 0. 001); resistance training had a significant effect on the increase of HIF1- (P = 0. 03), resistance training (P = 0. 02) and endurance training (P = 0. 001) had a significant effect on the increase of VEGF. Also, resistance training with cadmium consumption as well as endurance training with cadmium consumption significantly decreased HIF1- (P = 0. 001) and VEGF (P = 0. 001), compared with cadmium consumption. Conclusions: Cadmium appears to lead to an abnormal increase in HIF-1 and VEGF in the heart tissues of pregnant rats, which can stimulate abnormal angiogenesis of tumors; however, resistance and endurance training can reduce the severity of cadmium effects on abnormal angiogenesis of the heart tissue of pregnant rats.

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APA: Copy

Torabimehr, Farzaneh, KAZEMI, NASIBEH, & HOSSEINI, SEYED ALI. (2019). Effects of Resistance and Endurance Training on HIF-1 and VEGF in Heart Tissues of Pregnant Rats with Cadmium Toxicity. GENE, CELL AND TISSUE, 6(1), 0-0. SID. https://sid.ir/paper/969635/en

Vancouver: Copy

Torabimehr Farzaneh, KAZEMI NASIBEH, HOSSEINI SEYED ALI. Effects of Resistance and Endurance Training on HIF-1 and VEGF in Heart Tissues of Pregnant Rats with Cadmium Toxicity. GENE, CELL AND TISSUE[Internet]. 2019;6(1):0-0. Available from: https://sid.ir/paper/969635/en

IEEE: Copy

Farzaneh Torabimehr, NASIBEH KAZEMI, and SEYED ALI HOSSEINI, “Effects of Resistance and Endurance Training on HIF-1 and VEGF in Heart Tissues of Pregnant Rats with Cadmium Toxicity,” GENE, CELL AND TISSUE, vol. 6, no. 1, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/969635/en

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