The Effect of Vitamin E on the Expression of Mitochondrial Apoptotic Pathway genes in the Cerebellar Tissue of the Parkinson’ s Rat Model

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Jamali Behdokht; ENTEZARI MALIHEH; Babaei Nahid; HASHEMI MEHRDAD

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Journal Paper

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Journal: Archives of Advances in Biosciences Year:2021 | Volume:12 | Issue:4 Page(s): 12-17

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Title

The Effect of Vitamin E on the Expression of Mitochondrial Apoptotic Pathway genes in the Cerebellar Tissue of the Parkinson’ s Rat Model

Author(s)

Jamali Behdokht | ENTEZARI MALIHEH | Babaei Nahid | HASHEMI MEHRDAD | Issue Writer Certificate

Keywords

Rat

Bax

Bcl-2

Parkinson’s disease

Abstract

Introduction: Parkinson’ s disease is one of the debilitating diseases which is more common amongst the elderly; oxidative stress has been found to be one of its major causes. In this study, therefore, the effect of vitamin E on the expression of Bcl-2 family genes was studied. Materials and Methods: A total of 24 adult Rats were purchased from the Pasteur Institute of Iran. The Rats were later divided into 4 groups: control group, control group receiving VitE, PD group, PD group receiving VitE. After RNA extraction, cDNA synthesis, and primer design of Bax and Bcl-2 genes, their expressions were studied in different Rat groups by real-time polymerase chain reaction (RT-PCR) technique. Results: The mitochondrial apoptotic gene expressions were affected by vitamin E administRation. Vitamin E decreased the expression of Bax gene and overexpressed Bcl-2 gene. Conclusion: Vitamin E plays an important role in reducing the effects of oxidative stress and, consequently, apoptosis in the cerebellar tissue cells of Rats with Parkinson’ s disease.

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APA: Copy

Jamali, Behdokht, ENTEZARI, MALIHEH, Babaei, Nahid, & HASHEMI, MEHRDAD. (2021). The Effect of Vitamin E on the Expression of Mitochondrial Apoptotic Pathway genes in the Cerebellar Tissue of the Parkinson’ s Rat Model. ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES), 12(4), 12-17. SID. https://sid.ir/paper/970715/en

Vancouver: Copy

Jamali Behdokht, ENTEZARI MALIHEH, Babaei Nahid, HASHEMI MEHRDAD. The Effect of Vitamin E on the Expression of Mitochondrial Apoptotic Pathway genes in the Cerebellar Tissue of the Parkinson’ s Rat Model. ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES)[Internet]. 2021;12(4):12-17. Available from: https://sid.ir/paper/970715/en

IEEE: Copy

Behdokht Jamali, MALIHEH ENTEZARI, Nahid Babaei, and MEHRDAD HASHEMI, “The Effect of Vitamin E on the Expression of Mitochondrial Apoptotic Pathway genes in the Cerebellar Tissue of the Parkinson’ s Rat Model,” ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES), vol. 12, no. 4, pp. 12–17, 2021, [Online]. Available: https://sid.ir/paper/970715/en

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