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Information Journal Paper

Title

Door-to-antibiotic Time and In-hospital Mortality of Elder Patients Presenting to Emergency Department with Sepsis; a Cross-Sectional Study

Pages

  0-0

Abstract

 Introduction: The current international Sepsis guideline recommends that administration of intravenous broad-spectrum antibiotics should be initiated within 1 hour of emergency department (ED) arrival for Sepsis patients. This study aimed to evaluate the association between door-to-antibiotic time and in-Hospital Mortality of these patients. Methods: In this retrospective cross-sectional study, elderly patients (age ¸ 65 years) diagnosed with Sepsis in the ED of a tertiary referral and academic Hospital from January to December 2019 were enrolled. Door-to-antibiotic time was defined as the time from ED arrival to antibiotic initiation. The associations of door-to-antibiotic time and each hour delay in first antibiotic initiation with in-Hospital Mortality were assessed. Results: Six hundred patients with the median age of 78. 0 (IQR: 72. 0-86. 0) were studied (50. 8% female). The median door-to-antibiotic time was 51. 0 (36. 0– 89. 0) minutes and in-Hospital Mortality rate was 12. 5%. There was no significant difference in the in-Hospital Mortality rate between door-to-antibiotic time · 1 hour and >1 hour (13. 1% vs. 11. 6%, p = 0. 726). When considering hour-upon-hour of door-to-antibiotic time, no significant difference in in-Hospital Mortality was observed (p = 0. 866). Factors that led to a delay in doorto-antibiotic time were presenting body temperature <38° C (odds ratio [OR] 3. 34; 95% CI, 2. 12-5. 29; p < 0. 001) and age <75 years (OR 1. 7; 95% CI, 1. 09-2. 64; p= 0. 019). Conclusion: Door-to-antibiotic time was not associated with in-Hospital Mortality in elderly Sepsis patients in this study. Significant factors that led to a delay in door-to-antibiotic time were no fever, age <75 years, doctor time, and blood sample taking time.

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    APA: Copy

    Tantarattanapong, Siriwimon, & Hemwej, Thanaporn. (2021). Door-to-antibiotic Time and In-hospital Mortality of Elder Patients Presenting to Emergency Department with Sepsis; a Cross-Sectional Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 9(1), 0-0. SID. https://sid.ir/paper/973954/en

    Vancouver: Copy

    Tantarattanapong Siriwimon, Hemwej Thanaporn. Door-to-antibiotic Time and In-hospital Mortality of Elder Patients Presenting to Emergency Department with Sepsis; a Cross-Sectional Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/973954/en

    IEEE: Copy

    Siriwimon Tantarattanapong, and Thanaporn Hemwej, “Door-to-antibiotic Time and In-hospital Mortality of Elder Patients Presenting to Emergency Department with Sepsis; a Cross-Sectional Study,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/973954/en

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