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Information Journal Paper

Title

A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients

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Abstract

 Background: Oxidative Stress as a major mediator of adverse outcomes in kidney transplant recipients who are prone to Oxidative Stress-mediated injury by pre-transplant and post-transplant conditions. Objectives: The purpose of this study was to assess the eff ects of Pioglitazone on Oxidative Stress biomarkers and blood glucose control in diabetic patients receiving insulin after Kidney Transplantation. Methods: In a triple-blind randomized placebo-controlled trial, sixty-two kidney transplanted diabetic patients (40 men and 24 women) were followed for 4 months after randomly assigned to the placebo group and Pioglitazone group (30 mg/d). All of the patients continued their insulin therapy irrespective of the group that they were assigned to evaluate the eff ects of the addition of Pioglitazone on blood glucose and Oxidative Stress biomarkers, Malondialdehyde (MDA) and total protein carbonyls (TPC) serum levels. Results: At baseline, there were no statistically signifi cant diff erences in glycemic control levels and oxidative markers between the two groups. After 4 months of intervention, a signifi cant improvement occurred in Hemoglobin A1c (HBA1c) in the Pioglitazone group. The changes of HBA1c during 4 months of follow up in the Pioglitazone group show improvement in glucose control were as HBA1c in the placebo group increased by 0. 3% (P = 0. 0001). Moreover, at the end of the study, the MDA level was signifi cantly lower in the Pioglitazone group (P < 0. 0001, 1. 22-3. 90). Regarding the serum level of TPC, the changes were not statistically diff erent at baseline and also at the end of the study between two groups. Conclusions: Administration of Pioglitazone in addition to insulin in diabetic kidney transplant patients not only improved glycemic control (evidenced by HBA1c) but also signifi cantly decreased Oxidative Stress markers such as MDA.

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    APA: Copy

    KHARAZMKIA, ALI, AHMADPOOR, PEDRAM, MORADI, OMID, KHOSHDEL, ALI, POUR REZA GHOLI, FATEMEH, SAMAVAT, SHIVA, SAMADIAN, FARIBA, & NAFAR, MOHSEN. (2020). A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients. SHIRAZ E MEDICAL JOURNAL, 21(11), 0-0. SID. https://sid.ir/paper/974398/en

    Vancouver: Copy

    KHARAZMKIA ALI, AHMADPOOR PEDRAM, MORADI OMID, KHOSHDEL ALI, POUR REZA GHOLI FATEMEH, SAMAVAT SHIVA, SAMADIAN FARIBA, NAFAR MOHSEN. A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients. SHIRAZ E MEDICAL JOURNAL[Internet]. 2020;21(11):0-0. Available from: https://sid.ir/paper/974398/en

    IEEE: Copy

    ALI KHARAZMKIA, PEDRAM AHMADPOOR, OMID MORADI, ALI KHOSHDEL, FATEMEH POUR REZA GHOLI, SHIVA SAMAVAT, FARIBA SAMADIAN, and MOHSEN NAFAR, “A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients,” SHIRAZ E MEDICAL JOURNAL, vol. 21, no. 11, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/974398/en

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