The Relationship Between Adiponectin Serum Level and Coronary Artery Disease in Type 2 Diabetic Patients

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MAZLOUM KHORASANI ZAHRA; Choobkar Saeed; KHAMENEH BAGHERI RAMIN; AkbariRad Mina; FIROOZI ABDOLLAH

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Journal Paper

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Journal: ACTA MEDICA IRANICA Year:2021 | Volume:59 | Issue:3 Page(s): 142-147

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Title

The Relationship Between Adiponectin Serum Level and Coronary Artery Disease in Type 2 Diabetic Patients

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Keywords

Type 2 diabetes

Adiponectin

Coronary artery disease

Abstract

Adiponectin is an adipocytokine that has a higher serum level in healthy people. In Type 2 diabetes, insulin resistance, hypertension, MI, and dyslipidemia, the serum level of Adiponectin is lower than 4 μ g/mL. Adiponectin is proved to have a protective role against atherosclerotic changes where its low serum levels in Type 2 diabetes can lead to the progression of atherosclerotic lesions. In this study, we aimed to survey the possible effects of Adiponectin in the development of Coronary artery disease in type 2 diabetics. Thirty diabetic cases with Coronary artery disease, 30 diabetic cases without known Coronary artery disease, and a group of 30 healthy volunteers, all of them were between 18-65-year-old, were entered our study. We gathered demographic data by performing a physical examination followed by filling a checklist and a set of laboratory tests. All the groups were sex and age-matched (P=0. 284 and P=0. 163 respectively). CAD group had the lowest HBA1C (P<0. 001). Both LDL and HDL were also lower in the CAD group (P<0. 001). Adiponectin was also lower in the CAD group when compared to other groups (P<0. 008) or when compared with only normal diabetics (P<0. 002). We found a correlation between Adiponectin and HDL (r=0. 348, P=0. 008), suggesting each unit of reduction in serum level of Adiponectin could increase the chance of Coronary artery disease by 38% in diabetics. In this study, we showed that the lower serum level of Adiponectin is correlated with an increased risk of Coronary artery disease in type 2 diabetics.

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APA: Copy

MAZLOUM KHORASANI, ZAHRA, Choobkar, Saeed, KHAMENEH BAGHERI, RAMIN, AkbariRad, Mina, & FIROOZI, ABDOLLAH. (2021). The Relationship Between Adiponectin Serum Level and Coronary Artery Disease in Type 2 Diabetic Patients. ACTA MEDICA IRANICA, 59(3), 142-147. SID. https://sid.ir/paper/974404/en

Vancouver: Copy

MAZLOUM KHORASANI ZAHRA, Choobkar Saeed, KHAMENEH BAGHERI RAMIN, AkbariRad Mina, FIROOZI ABDOLLAH. The Relationship Between Adiponectin Serum Level and Coronary Artery Disease in Type 2 Diabetic Patients. ACTA MEDICA IRANICA[Internet]. 2021;59(3):142-147. Available from: https://sid.ir/paper/974404/en

IEEE: Copy

ZAHRA MAZLOUM KHORASANI, Saeed Choobkar, RAMIN KHAMENEH BAGHERI, Mina AkbariRad, and ABDOLLAH FIROOZI, “The Relationship Between Adiponectin Serum Level and Coronary Artery Disease in Type 2 Diabetic Patients,” ACTA MEDICA IRANICA, vol. 59, no. 3, pp. 142–147, 2021, [Online]. Available: https://sid.ir/paper/974404/en

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