Evaluation of CD44 and TGF-B Expression in Oral Carcinogenesis

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GHAZI NARGES; SAGHRAVANIAN NASROLLAH; SHAKERI MOHAMMAD TAGHI; Jamali Mounes

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Journal: JOURNAL OF DENTISTRY Year:2021 | Volume:22 | Issue:1 Page(s): 33-40

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Title

Evaluation of CD44 and TGF-B Expression in Oral Carcinogenesis

Author(s)

GHAZI NARGES | SAGHRAVANIAN NASROLLAH | SHAKERI MOHAMMAD TAGHI | Jamali Mounes | Issue Writer Certificate

Keywords

Oral squamous cell carcinoma

Dysplasia

CD44

TGF-B

Abstract

Statement of the Problem: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. Early diagnosis of OSCC by using biomarkers provides pre-ventive treatment approach to suppress the disease in early stages. CD44 as a cancer stem cell (CSC) marker may be cleaved by MT1-MMP and plays an important role in migration of cancer cells. TGF-B promotes formation of invasive cancer cells phenotype through epithelial mesenchymal transition (EMT) and induces MT1-MMP formation. Purpose: The aim of this study was to evaluate the expression of TGF-B and CD44 in leukoplakia (premalignant lesion), squamous cell carcinoma (SCC), and normal oral muco-sa to determine the role of these markers in the carcinogenesis process of the oral mucosa. Materials and Method: In this retrospective study, the expression of TGF-B and CD44 were evaluated in 55 paraffin-embedded specimens (10normal mucosa, 15 non-dysplastic leukoplakia, 15 dysplastic leukoplakia, and 15 OSCC) by immunohistochemistry. Statistical analyses were performed using Kruskal-Wallis, Mann-Whitney, and Spearman’ s rank cor-relation tests. Results: Evaluation of CD44 and TGF-B expression in the four studied groups showed statistical significant difference for each marker (p< 0. 001). Pairwise comparison of CD44 and TGF-B expression in all groups except normal mucosa and non-dysplastic leukoplakia demonstrated statistical significant difference. In addition, there was positive significant correlation between two markers (r= 0. 914, p< 0. 001). Diagnostic test’ s accuracy for identi-fication of OSCC and dysplastic leukoplakia from non-dysplastic leukoplakia and normal tissues and recognition of OSCC from dysplastic leukoplakia showed optimum sensitivity and specificity. Conclusion: Increased expression of CD44 as a cancer stem cell marker and TGF-B as an EMT marker from normal mucosa to non-dysplastic leukoplakia, dysplastic leukoplakia, and OSCC and also the significant correlation between these two markers indicated their role in carcinogenesis of oral mucosa.

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References

Deciphering the Dynamics of Epithelial-Mesenchymal Transition and Cancer Stem Cells in Tumor Progression

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APA: Copy

GHAZI, NARGES, SAGHRAVANIAN, NASROLLAH, SHAKERI, MOHAMMAD TAGHI, & Jamali, Mounes. (2021). Evaluation of CD44 and TGF-B Expression in Oral Carcinogenesis. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 22(1), 33-40. SID. https://sid.ir/paper/974549/en

Vancouver: Copy

GHAZI NARGES, SAGHRAVANIAN NASROLLAH, SHAKERI MOHAMMAD TAGHI, Jamali Mounes. Evaluation of CD44 and TGF-B Expression in Oral Carcinogenesis. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2021;22(1):33-40. Available from: https://sid.ir/paper/974549/en

IEEE: Copy

NARGES GHAZI, NASROLLAH SAGHRAVANIAN, MOHAMMAD TAGHI SHAKERI, and Mounes Jamali, “Evaluation of CD44 and TGF-B Expression in Oral Carcinogenesis,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 22, no. 1, pp. 33–40, 2021, [Online]. Available: https://sid.ir/paper/974549/en

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