Penetration of Carbon Nanotubes into the Retinoblastoma Tumor after Intravitreal Injection in LHBETABETABETA TAGAGAG Transgenic Mice Reti-noblastoma Model

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DEMIRCI HAKAN; Wang Yichun; Li Qiaochu; Lin Cheng mao; Kotov Nicholas A.; Diniz Grisolia Anna Beatriz; Guo Jay L.

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Journal Paper

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Journal: Journal of Ophthalmic and Vision Research Year:2020 | Volume:15 | Issue:4 Page(s): 446-452

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Title

Penetration of Carbon Nanotubes into the Retinoblastoma Tumor after Intravitreal Injection in LHBETABETABETA TAGAGAG Transgenic Mice Reti-noblastoma Model

Author(s)

Keywords

Carbon nanotubes

Intravitreal Injection

LHBETATAG Transgenic Mice Retinoblastoma Model

Nanoparticle

Nanotubes

Retinoblastoma

Abstract

Purpose: To evaluate the penetration of Nanotubes/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Carbon Nanotubes (CNTs) throughout Retinoblastoma in a transgenic mice model. Methods: CNTs functionalized with fluorescein isothiocyanate and targeting ligands biotin (CTN-FITC-Bio, 0. 5mg/ml), or folic acid (CNT-FITC-FA, 0. 5mg/ml) were injected into the vitreous of one eye of LHBETA TAG transgenic mice. Other eye did not receive any injection and was used as control. Three mice were sacrificed at days 1, 2, and 3. Eyes were enucleated and stained with 4, 6-diamidino-2-phenylindole. The sections were imaged by fluorescent microscope. The images were transformed into grey-scale in MATLAB for intensity analysis. Background intensity was normalized by marking squares outside the eyeball and using the mean intensity of these squares. Fluorescent intensity (FI) for each image was measured by calculating the intensity of a same-sized square within Retinoblastoma. Results: Nine eyes of nine mice were included in each CNT-FITC-Bio and CNT-FITC-FA groups. The mean FI in CNT-FITCBio was 52. 08 ± 6. 33, 53. 62 ± 9. 00, and 65. 54 ± 5. 14 in days 1, 2, and 3, respectively. The mean FI in CNT-FITC-FA was 50. 28 ± 7. 37, 59. 21 ± 6. 43, and 58. 38 ± 2. 32 on days 1, 2, and 3, respectively. FI was significantly higher in eyes injected with CNT-FITC-Bio and CNT-FITC-FA compared to the control eyes (P = 0. 02). There was no difference in FI between eyes with CNT-FITC-Bio and CNT-FITC-FA, and FI remained stable on days 1– 3 in CNT-FITC-Bio, CNT-FITC-FA, and control eyes (P > 0. 05). Conclusion: We observed higher FI in eyes with CNT-FITC-Bio and CNT-FITC-FA compared to control eyes, showing penetration of CNTs throughout Retinoblastoma. CNTs can be a carrier candidate for imaging or therapeutic purposes in Retinoblastoma.

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APA: Copy

DEMIRCI, HAKAN, Wang, Yichun, Li, Qiaochu, Lin, Cheng mao, Diniz Grisolia, Anna Beatriz, & Guo, Jay L.. (2020). Penetration of Carbon Nanotubes into the Retinoblastoma Tumor after Intravitreal Injection in LHBETABETABETA TAGAGAG Transgenic Mice Reti-noblastoma Model. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 15(4), 446-452. SID. https://sid.ir/paper/978388/en

Vancouver: Copy

DEMIRCI HAKAN, Wang Yichun, Li Qiaochu, Lin Cheng mao, Diniz Grisolia Anna Beatriz, Guo Jay L.. Penetration of Carbon Nanotubes into the Retinoblastoma Tumor after Intravitreal Injection in LHBETABETABETA TAGAGAG Transgenic Mice Reti-noblastoma Model. JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2020;15(4):446-452. Available from: https://sid.ir/paper/978388/en

IEEE: Copy

HAKAN DEMIRCI, Yichun Wang, Qiaochu Li, Cheng mao Lin, Anna Beatriz Diniz Grisolia, and Jay L. Guo, “Penetration of Carbon Nanotubes into the Retinoblastoma Tumor after Intravitreal Injection in LHBETABETABETA TAGAGAG Transgenic Mice Reti-noblastoma Model,” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 15, no. 4, pp. 446–452, 2020, [Online]. Available: https://sid.ir/paper/978388/en

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