Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy

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Pashapour Anousheh Jeiran; BARZEGAR ABOLFAZL; HEJAZI MOHAMMAD SAEID; Hasheminejad Nikoo; Heidari Hamid Reza; MEHDIZADEH AGHDAM ELNAZ

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Journal Paper

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Journal: PHARMACEUTICAL SCIENCES Year:2022 | Volume:28 | Issue:1 Page(s): 5-14

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Title

Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy

Author(s)

Keywords

Ras

Drug development

Cancer therapy

Structural drug design

Abstract

Ras proteins are considered as one of the most critical cancer initiators. Mutations of this protein family lead to the continuous activation of the proliferation pathways. Therefore, many efforts have been taken to design the anti-mutant Ras drug candidates. Regardless of the development of promising inhibitors of Ras G12C mutant in a specific cancer type, there is no approved inhibitor of Ras mutants in the clinic. One of the significant limitations is to inhibit particular mutants and not to affect the wild-type Ras variants. Here we present a review on the mechanism of action of the Ras proteins to get a better insight into the strategies utilized to inhibit Ras-mutated cancers. The direct Ras inhibition strategies are then highlighted to obtain a better perspective of possible promising approaches to target Ras proteins in Cancer therapy.

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APA: Copy

Pashapour Anousheh, Jeiran, BARZEGAR, ABOLFAZL, HEJAZI, MOHAMMAD SAEID, Hasheminejad, Nikoo, Heidari, Hamid Reza, & MEHDIZADEH AGHDAM, ELNAZ. (2022). Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy. PHARMACEUTICAL SCIENCES, 28(1), 5-14. SID. https://sid.ir/paper/979747/en

Vancouver: Copy

Pashapour Anousheh Jeiran, BARZEGAR ABOLFAZL, HEJAZI MOHAMMAD SAEID, Hasheminejad Nikoo, Heidari Hamid Reza, MEHDIZADEH AGHDAM ELNAZ. Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy. PHARMACEUTICAL SCIENCES[Internet]. 2022;28(1):5-14. Available from: https://sid.ir/paper/979747/en

IEEE: Copy

Jeiran Pashapour Anousheh, ABOLFAZL BARZEGAR, MOHAMMAD SAEID HEJAZI, Nikoo Hasheminejad, Hamid Reza Heidari, and ELNAZ MEHDIZADEH AGHDAM, “Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy,” PHARMACEUTICAL SCIENCES, vol. 28, no. 1, pp. 5–14, 2022, [Online]. Available: https://sid.ir/paper/979747/en

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