Synthesis of new three-component derivatives of 1, 3, 4-oxadiazole and evaluation of their in vitro antibacterial and antifungal properties

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ZARRABI AHRABI NAKISA; SOULDOZI ALI; SarveAhrabi Yasin

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Journal Paper

Paper Information

Journal: MEDICAL LABORATORY JOURNAL Year:2021 | Volume:15 | Issue:5 Page(s): 13-18

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Information Journal Paper

Title

Synthesis of new three-component derivatives of 1, 3, 4-oxadiazole and evaluation of their in vitro antibacterial and antifungal properties

Author(s)

ZARRABI AHRABI NAKISA | SOULDOZI ALI | SarveAhrabi Yasin | Issue Writer Certificate

Keywords

Anti-bacterial agents

Antifungal agents

Oxadiazoles

Abstract

Background and objectives: Antibiotic resistance is a major public health challenge. The pervasive antibiotic misuse can lead to increased antibiotic resistance. Thus, there is a need for discovery of new compounds against drug-resistant microorganisms. We synthesized new series of 1, 3, 4-oxadiazole derivatives (4a-4d) and evaluated the antibacterial and antifungal activity of the derivatives against Staphylococcus aureus, Staphylococcus epidermidis, Acinetobacter baumannii, Klebsiella pneumoniae, Aspergillus fumigatus and Aspergillus flavus. Methods: The new derivatives of 1, 3, 4-oxadiazole were synthesized using a single-stage, high-yield method. The structure of the new compounds was confirmed by infrared spectroscopy, carbon-nuclear magnetic resonance and hydrogen-nuclear magnetic resonance. Then, antibacterial and antifungal activities of the prepared derivatives (1 mg/ml) were evaluated by determining minimum inhibitory concentration and minimum bactericidal/fungicidal concentration using the agar well diffusion method. Results: All synthesized compounds, especially (4d) with methoxyphenyl group, exhibited powerful antibacterial activity against the tested bacteria. However, the compounds had no antifungal effect. Conclusion: Our findings indicate the antibacterial potential of the novel synthetic 1, 3, 4-oxadiazole compounds.

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Cites

Anti-Helicobacter pylori Activity of New Derivatives of 1, 3, 4-Oxadiazole: In Silico Study

References

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APA: Copy

ZARRABI AHRABI, NAKISA, SOULDOZI, ALI, & SarveAhrabi, Yasin. (2021). Synthesis of new three-component derivatives of 1, 3, 4-oxadiazole and evaluation of their in vitro antibacterial and antifungal properties. MEDICAL LABORATORY JOURNAL, 15(5), 13-18. SID. https://sid.ir/paper/981383/en

Vancouver: Copy

ZARRABI AHRABI NAKISA, SOULDOZI ALI, SarveAhrabi Yasin. Synthesis of new three-component derivatives of 1, 3, 4-oxadiazole and evaluation of their in vitro antibacterial and antifungal properties. MEDICAL LABORATORY JOURNAL[Internet]. 2021;15(5):13-18. Available from: https://sid.ir/paper/981383/en

IEEE: Copy

NAKISA ZARRABI AHRABI, ALI SOULDOZI, and Yasin SarveAhrabi, “Synthesis of new three-component derivatives of 1, 3, 4-oxadiazole and evaluation of their in vitro antibacterial and antifungal properties,” MEDICAL LABORATORY JOURNAL, vol. 15, no. 5, pp. 13–18, 2021, [Online]. Available: https://sid.ir/paper/981383/en

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