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Information Journal Paper

Title

Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetic Patients

Pages

  180-186

Abstract

 Statement of the Problem: The association of genetic polymorphisms with periodontitis has been studied extensively. The interleukin-17 (IL-17) is a group of cytokines, which comprises six different molecules (IL-17A, B, C, D, E & F). Among these, IL-17A & F are the most commonly understood cytokine, which plays a critical role in inflammatory diseases and peri-odontal inflammation. Purpose: To evaluate whether IL-17A gene polymorphism is associated with increased risk of Chronic Periodontitis in type 1 diabetes patients. Materials and Method: This quantitative case-control study was carried out in 60 subjects in 4 groups. The study groups included group A: 15 type 1 diabetes patients (T1DM) with chron-ic periodontitis (CP), group B: 15 T1DM patients without CP, group C: 15 Non-diabetic pa-tients with CP, group D: 15 Non-diabetic patients without CP. Blood samples were drawn from the subjects and analyzed for IL-17A polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism method. Results: There was no statistical significant difference seen in the genotype distribution among CP patients with or without T1DM and healthy controls. Odds ratio and p value indi-cated that increased risks for CP were associated with IL-17A allele (G) in patients with T1DM. This allele was correlated with worse clinical parameters of CP in T1DM patients. Conclusion: The present study revealed that IL-17A (rs2275913) polymorphism was not associated with increased risk for CP in T1DM patients.

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    Cite

    APA: Copy

    Kumar PK, Sasi, Varghese S, Sheeja, Kumaran, Thanga, Desaan N, Jaga, & Daran G, Lambo. (2021). Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetic Patients. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 22(3), 180-186. SID. https://sid.ir/paper/982721/en

    Vancouver: Copy

    Kumar PK Sasi, Varghese S Sheeja, Kumaran Thanga, Desaan N Jaga, Daran G Lambo. Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetic Patients. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2021;22(3):180-186. Available from: https://sid.ir/paper/982721/en

    IEEE: Copy

    Sasi Kumar PK, Sheeja Varghese S, Thanga Kumaran, Jaga Desaan N, and Lambo Daran G, “Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetic Patients,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 22, no. 3, pp. 180–186, 2021, [Online]. Available: https://sid.ir/paper/982721/en

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