Evaluation of Hepatotoxicity of Aqueous Extract of Valerian (Valeriana Officinalis) in Laboratory Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mohammadi Zinat; PISHKAR LEILA; BARZIN GITI; Babaeekhou Laleh

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2021 | Volume:29 | Issue:5 Page(s): 3757-3764

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Evaluation of Hepatotoxicity of Aqueous Extract of Valerian (Valeriana Officinalis) in Laboratory Mice

Author(s)

Mohammadi Zinat | PISHKAR LEILA | BARZIN GITI | Babaeekhou Laleh | Issue Writer Certificate

Keywords

Hepatotoxicity

ALT

AST

Valerian

Aqueous Extract

Abstract

Introduction: Concerns have been raised about the toxic effects of medicinal plants due to their increased consumption. Therefore, the aim of the present study was to investigate the hepatotoxic effects of Aqueous Extract of Valerian in laboratory mice. Methods: After preparation of plant materials and Aqueous Extract of Valerian, concentrations of 10 and 20 mg/kg body weight were administered to laboratory mice for 14 days. On the day 14th, blood samples were taken from the hearts of mice after anesthesia and the serum levels of the enzymes alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) were studied. Furthermore, the animals' weight was recorded at 0, 7 and 14 days and weight changes were also studied. Results: The results of the present study showed the concentration-dependent effects of Aqueous Extract of Valerian on increasing serum levels of liver enzymes such as ALT, AST, ALP and GGT and the highest serum levels of these enzymes were observed at a concentration of 20 mg/kg. Moreover, the concentration of 20 mg/kg Aqueous Extract of Valerian caused severe weight loss in mice over a period of 14 days. Conclusion: In general, it was concluded that a concentration of 20 mg/kg causes liver damage. However, low concentrations of 10 mg/kg Valerian extract showed no toxic effects on the liver. Therefore, in the formulations prepared from Valerian, attention to the concentration of the extract is very important and the use of lower concentrations to prevent Hepatotoxicity is very important.

Cites

No record.

References

No record.

Cite

APA: Copy

Mohammadi, Zinat, PISHKAR, LEILA, BARZIN, GITI, & Babaeekhou, Laleh. (2021). Evaluation of Hepatotoxicity of Aqueous Extract of Valerian (Valeriana Officinalis) in Laboratory Mice. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 29(5 ), 3757-3764. SID. https://sid.ir/paper/983324/en

Vancouver: Copy

Mohammadi Zinat, PISHKAR LEILA, BARZIN GITI, Babaeekhou Laleh. Evaluation of Hepatotoxicity of Aqueous Extract of Valerian (Valeriana Officinalis) in Laboratory Mice. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;29(5 ):3757-3764. Available from: https://sid.ir/paper/983324/en

IEEE: Copy

Zinat Mohammadi, LEILA PISHKAR, GITI BARZIN, and Laleh Babaeekhou, “Evaluation of Hepatotoxicity of Aqueous Extract of Valerian (Valeriana Officinalis) in Laboratory Mice,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 5 , pp. 3757–3764, 2021, [Online]. Available: https://sid.ir/paper/983324/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops