Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients?

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SOHRABI MASOUDREZA; GHOLAMI ALI; AMIRKALALI BAHAREH; TAHERIZADEH MAHSA; Kolahdoz Mahsa; SAFARNEZHAD TAMESHKEL FAHIMEH; Aghili Sheida; Hajibaba Marzieh; ZAMANI FARHAD; NASIRI TOOSI MOHSEN; KEYVANI HOSSEIN

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Journal: GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH Year:2021 | Volume:14 | Issue:3 Page(s): 229-236

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Title

Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients?

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Keywords

Fatty liver

Cytokine

Melatonin

Inflammation

Abstract

Aim: The associations between serum levels of melatonin and concentrations of tumor necrosis factor (TNF)-a and interleukin (IL)-6 were assessed among patients with different degrees of non-alcoholic fatty liver disease. Background: Non-alcoholic fatty liver disease (NAFLD) has become a very common worldwide disease. Methods: In this cross-sectional study, adult patients diagnosed with fatty liver disease by Fibroscan evaluation were included if they met the inclusion/exclusion criteria for NAFLD. The participants were categorized into the three following groups: 1) fibrosis> 9. 1KP and steatosis >290 dbm; 2) fibrosis: 6-9. 0 KP and steatosis 240-285; and 3) fibrosis < 5. 8 KP and steatosis<240 dbm. Post-fasting, 5 ml of venous blood was collected for laboratory assessment, and a questionnaire including demographic, anthropometric, laboratories and clinical data was completed. Results: A total of 97 participants were included. The mean age was 42. 21± 11 years, and 59 patients (60. 0%) were female. Melatonin levels as well as pro-inflammatory cytokines levels were correlated with advancing fibrosis and steatosis in univariate analysis. A significant association was observed between these cytokines and advancing fibrosis, severe steatosis levels, and melatonin concentrations. Furthermore, in the multiple linear regression model, melatonin levels showed a significant association with these cytokines. Conclusion: Melatonin may have protective effects on tissue injury during advancing liver fibrosis via cytokines modulation. Therefore, it can be considered as a potential therapeutic management strategy for NAFLD.

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APA: Copy

SOHRABI, MASOUDREZA, GHOLAMI, ALI, AMIRKALALI, BAHAREH, TAHERIZADEH, MAHSA, Kolahdoz, Mahsa, SAFARNEZHAD TAMESHKEL, FAHIMEH, Aghili, Sheida, Hajibaba, Marzieh, ZAMANI, FARHAD, NASIRI TOOSI, MOHSEN, & KEYVANI, HOSSEIN. (2021). Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients?. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 14(3), 229-236. SID. https://sid.ir/paper/983394/en

Vancouver: Copy

SOHRABI MASOUDREZA, GHOLAMI ALI, AMIRKALALI BAHAREH, TAHERIZADEH MAHSA, Kolahdoz Mahsa, SAFARNEZHAD TAMESHKEL FAHIMEH, Aghili Sheida, Hajibaba Marzieh, ZAMANI FARHAD, NASIRI TOOSI MOHSEN, KEYVANI HOSSEIN. Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients?. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2021;14(3):229-236. Available from: https://sid.ir/paper/983394/en

IEEE: Copy

MASOUDREZA SOHRABI, ALI GHOLAMI, BAHAREH AMIRKALALI, MAHSA TAHERIZADEH, Mahsa Kolahdoz, FAHIMEH SAFARNEZHAD TAMESHKEL, Sheida Aghili, Marzieh Hajibaba, FARHAD ZAMANI, MOHSEN NASIRI TOOSI, and HOSSEIN KEYVANI, “Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients?,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 14, no. 3, pp. 229–236, 2021, [Online]. Available: https://sid.ir/paper/983394/en

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