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Information Journal Paper

Title

Investigating the Eff ect of Expiratory Time Constant on Outcome in Intubated Patients with Acute Respiratory Failure Caused by COVID-19 in Critical Care Unit: A Research Study

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Abstract

 Background: The coronavirus disease 2019 (COVID-19) has a high prevalence and mortality worldwide. Thousands of patients with acute respiratory failure caused by COVID-19 are daily hospitalized in intensive care units (ICUs) around the world. Many of these patients require full mechanical respiratory support and long-term ventilator use. Using diff erent ventilators and calculating important variables can be helpful in meeting therapeutic needs of patients. Objectives: The aim of present study was to investigate the eff ect of expiratory time constant (RCEXP) on the course of treatment and duration of Mechanical Ventilation in patients with acute respiratory failure hospitalized in ICU. Methods: The present cross-sectional study was conducted on 60 patients with acute respiratory failure who were hospitalized in the ICU and underwent Mechanical Ventilation due to COVID-19 in the fi rst six months of 2020. The variables of RCEXP, lung Compliance and lung Resistance in all patients were recorded daily and analyzed. Then, based on clinical outcome, the patients were divided into two groups: the patients with wean outcome (N = 40) and those with death outcome (N = 20). Results: The mean  SD of lung Compliance in patients who were separated from ventilator and patients with death outcome were 74. 73 (18. 58) mL/cm H2O and 36. 92 (10. 56) mL/cm H2O, respectively, which was statistically signifi cant (P = 0. 001). The mean  SD of lung Resistance in patients who were separated from ventilator and patients with death outcome were calculated at 9. 25 (4. 62) and 14 (6. 5), respectively, which was statistically signifi cant (P = 0. 015). Also, there was a statistically signifi cant diff erence between the two groups in terms of mean  SD of RCEXP (0. 67 (0. 23) vs. 0. 49 (0. 19), P = 0. 010). Conclusions: According to the results of this study, there was a signifi cant diff erence between high Resistance, low Compliance, RCEXP, and weaning success of intubation in patients hospitalized in the ICU.

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    APA: Copy

    Eghtedari, Fatemeh, Fooladi, Shahnaz, MOHAMMADIAN ERDI, ALI, Shadman, Atefeh, & Yousefian, Mahzad. (2021). Investigating the Eff ect of Expiratory Time Constant on Outcome in Intubated Patients with Acute Respiratory Failure Caused by COVID-19 in Critical Care Unit: A Research Study. ANESTHESIOLOGY AND PAIN MEDICINE, 11(6), 0-0. SID. https://sid.ir/paper/983619/en

    Vancouver: Copy

    Eghtedari Fatemeh, Fooladi Shahnaz, MOHAMMADIAN ERDI ALI, Shadman Atefeh, Yousefian Mahzad. Investigating the Eff ect of Expiratory Time Constant on Outcome in Intubated Patients with Acute Respiratory Failure Caused by COVID-19 in Critical Care Unit: A Research Study. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2021;11(6):0-0. Available from: https://sid.ir/paper/983619/en

    IEEE: Copy

    Fatemeh Eghtedari, Shahnaz Fooladi, ALI MOHAMMADIAN ERDI, Atefeh Shadman, and Mahzad Yousefian, “Investigating the Eff ect of Expiratory Time Constant on Outcome in Intubated Patients with Acute Respiratory Failure Caused by COVID-19 in Critical Care Unit: A Research Study,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 11, no. 6, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/983619/en

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