مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Association of IL-22 and IL-22RA1 gene variants in Iranian patients with colorectal cancer

Pages

  58-65

Abstract

 Aim: In the current study, it was hypothesized that Single nucleotide polymorphisms (SNPs) in the regulatory region of the IL-22 signaling pathway genes, including IL-22 and IL-22RA1 variants, may be associated with CRC susceptibility. Background: The important role of pro-inflammatory cytokines during tumorigenesis is well-established. In recent years, IL-22 has been linked with Colorectal cancer (CRC) through a number of mechanistic and observational studies Methods: The association of four polymorphisms in the IL-22 (rs1179251 and rs1179246) and IL-22RA1 (rs4648936 and rs10794665) genes with CRC risk were studied using a case-control design with 304 cases and 345 controls from the Iranian population. All 649 subjects were evaluated by PCR– RFLP method. Results: No significant difference was found in genotype and allele frequencies between the cases and controls for either IL-22 and IL-22RA1 gene variants or CRC risk before or after adjusting for confounders. Conclusion: The current findings do not present any significant evidence for associations between variants in IL-22 signaling pathway genes and CRC. Complementary studies with greater sample sizes may be necessary to fully elucidate the nature of these associations.

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    APA: Copy

    MOHEBBI, SEYED REZA, KARIMI, KHATOON, ROSTAMI, FATEMEH, KAZEMIAN, SHABNAM, AZIMZADEH, PEDRAM, Mirtalebi, Hanieh, NAZEMALHOSSEINI MOJARAD, EHSAN, ASADZADEH AGHDAEI, HAMID, VAFAEE, REZA, & Heydari, Mohammad Hossain. (2021). Association of IL-22 and IL-22RA1 gene variants in Iranian patients with colorectal cancer. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 14(suppl1), 58-65. SID. https://sid.ir/paper/984534/en

    Vancouver: Copy

    MOHEBBI SEYED REZA, KARIMI KHATOON, ROSTAMI FATEMEH, KAZEMIAN SHABNAM, AZIMZADEH PEDRAM, Mirtalebi Hanieh, NAZEMALHOSSEINI MOJARAD EHSAN, ASADZADEH AGHDAEI HAMID, VAFAEE REZA, Heydari Mohammad Hossain. Association of IL-22 and IL-22RA1 gene variants in Iranian patients with colorectal cancer. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2021;14(suppl1):58-65. Available from: https://sid.ir/paper/984534/en

    IEEE: Copy

    SEYED REZA MOHEBBI, KHATOON KARIMI, FATEMEH ROSTAMI, SHABNAM KAZEMIAN, PEDRAM AZIMZADEH, Hanieh Mirtalebi, EHSAN NAZEMALHOSSEINI MOJARAD, HAMID ASADZADEH AGHDAEI, REZA VAFAEE, and Mohammad Hossain Heydari, “Association of IL-22 and IL-22RA1 gene variants in Iranian patients with colorectal cancer,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 14, no. suppl1, pp. 58–65, 2021, [Online]. Available: https://sid.ir/paper/984534/en

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