THE EFFECTS OF CABERGOLINE ON PITUITARY– THYROID HORMONES IN ADULT MALE RATS

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MOKHTARI MOKHTAR; SHARIATI MEHRDAD; PASHA LALEH

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2010 | Volume:20 | Issue:3 Page(s): 164-169

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Title

THE EFFECTS OF CABERGOLINE ON PITUITARY– THYROID HORMONES IN ADULT MALE RATS

Author(s)

MOKHTARI MOKHTAR | SHARIATI MEHRDAD | PASHA LALEH | Issue Writer Certificate

Keywords

CABERGOLINEQ3

TSHQ3

T4Q3

T3Q2

RATQ3

Abstract

Background: CABERGOLINE is a strong dopaminergic agonist that is derived from Ergot fungus. Although, this drug can be so important in treating many disorders such as hyperprolactinemia, but its side effects are considerable on the endocrinal axis. The purpose of this study was to determine effects of CABERGOLINE on serum levels of TSH, T4 and T3 hormones in adult male RATs.Materials and methods: In this experimental study, 40 adult male wistar RATs were used in five groups of eight. The drug was subcutaneously injected for a period of 14 days. The experimental groups received 0.1, 0.5 and 1 mg/kg, respectively. The control group received no drug. The sham group received only distilled water. At the end of 14th day, blood samples were taken and the concentration of TSH, T4 and T3 were measured by RIA. The results were analyzed by ANOVA and TUKEY test between the control and experimental group. Results: Serum levels of TSH and T4 hormones in the experimental groups with doses of 0.1, 0.5 and 1 mg/kg showed statistically significant decrease compared with control group (p<0.05). Concentration of T3 hormone showed significant increase in the experimental group with 0.1 mg/kg in comparison with control group (p<0.05).Conclusion: CABERGOLINE probably decreases the release of TSH and T4 by stimulating the D2-dopaminergic receptor existing in thyrotrophic cells. According to the increase of T3 concentration with low dose of drug, CABERGOLINE may have different physiological effects in different amounts, and alter the function of pituitary –thyroid axis.

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APA: Copy

MOKHTARI, MOKHTAR, SHARIATI, MEHRDAD, & PASHA, LALEH. (2010). THE EFFECTS OF CABERGOLINE ON PITUITARY– THYROID HORMONES IN ADULT MALE RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 20(3), 164-169. SID. https://sid.ir/paper/98475/en

Vancouver: Copy

MOKHTARI MOKHTAR, SHARIATI MEHRDAD, PASHA LALEH. THE EFFECTS OF CABERGOLINE ON PITUITARY– THYROID HORMONES IN ADULT MALE RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2010;20(3):164-169. Available from: https://sid.ir/paper/98475/en

IEEE: Copy

MOKHTAR MOKHTARI, MEHRDAD SHARIATI, and LALEH PASHA, “THE EFFECTS OF CABERGOLINE ON PITUITARY– THYROID HORMONES IN ADULT MALE RATS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 20, no. 3, pp. 164–169, 2010, [Online]. Available: https://sid.ir/paper/98475/en

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