ROLES OF MIRNAS IN GENE EXPRESSION REGULATION, APOPTOSIS, DIAGNOSIS AND TREATMENT OF CANCER

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NOORI DALOII MOHAMMAD REZA; VAND RAJABPOUR FATEMEH

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2011 | Volume:21 | Issue:3 (65) Page(s): 151-161

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Title

ROLES OF MIRNAS IN GENE EXPRESSION REGULATION, APOPTOSIS, DIAGNOSIS AND TREATMENT OF CANCER

Author(s)

NOORI DALOII MOHAMMAD REZA | VAND RAJABPOUR FATEMEH | Issue Writer Certificate

Keywords

APOPTOSISQ1

MIRNAQ2

CANCERQ2

PROAPOPTOTICQ2

ANTIAPOPTOTICQ2

MIRTRONQ2

Abstract

APOPTOSIS, as a programmed cell death, is activated in response to various stresses. APOPTOSIS is an active and energy need process that many mechanisms and genetic factors control it with specific programs.Apoptotic cells have specific features. APOPTOSIS acts in many different organic evolutionary stages. Aberrations in regulation of this process can cause many diseases, such as CANCERs. Different molecules, like MIRNAs, have a role in APOPTOSIS process. MIRNAs, as regulatory molecules, act in abundant cellular mechanisms. Regarding their function, apoptotic related MIRNAs were divided in PROAPOPTOTIC and ANTIAPOPTOTIC groups. MIRNAs target several mRNAs and also themselves were regulated by other genes. This regulatory loop between MIRNAs and related genes cause complexity. MIRNAs have different expression profile in normal and abnormal cells. APOPTOSIS and MIRNA both act in different processes of tumorigenesis, metastasis and antiogenesis. MIRNAs can be used as biomarkers in prevention, prognosis and prevention of different CANCERs.Advances in knowledge about MIRNAs lead to develop new therapeutic trend.Recent researches have suggested using MIRNAs involved in APOPTOSIS in the treatment of CANCERs.

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APA: Copy

NOORI DALOII, MOHAMMAD REZA, & VAND RAJABPOUR, FATEMEH. (2011). ROLES OF MIRNAS IN GENE EXPRESSION REGULATION, APOPTOSIS, DIAGNOSIS AND TREATMENT OF CANCER. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 21(3 (65)), 151-161. SID. https://sid.ir/paper/98512/en

Vancouver: Copy

NOORI DALOII MOHAMMAD REZA, VAND RAJABPOUR FATEMEH. ROLES OF MIRNAS IN GENE EXPRESSION REGULATION, APOPTOSIS, DIAGNOSIS AND TREATMENT OF CANCER. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2011;21(3 (65)):151-161. Available from: https://sid.ir/paper/98512/en

IEEE: Copy

MOHAMMAD REZA NOORI DALOII, and FATEMEH VAND RAJABPOUR, “ROLES OF MIRNAS IN GENE EXPRESSION REGULATION, APOPTOSIS, DIAGNOSIS AND TREATMENT OF CANCER,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 21, no. 3 (65), pp. 151–161, 2011, [Online]. Available: https://sid.ir/paper/98512/en

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