The Effect of Resveratrol against Acrolein Toxicity in Mitochondria isolated from Rat Liver

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SHAFIEI BEHNAZ; POURAHMAD JALAL; REZAEI MOHSEN

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Journal Paper

Paper Information

Journal: Journal of North Khorasan University of Medical Sciences Year:2019 | Volume:11 | Issue:1 Page(s): 51-57

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Information Journal Paper

Title

The Effect of Resveratrol against Acrolein Toxicity in Mitochondria isolated from Rat Liver

Author(s)

SHAFIEI BEHNAZ | POURAHMAD JALAL | REZAEI MOHSEN | Issue Writer Certificate

Keywords

Acrolein

Mitochondria

Resveratrol

Stress Oxidative

Abstract

Introduction: Acrolein is an important environmental, food and water pollutant that plays an important role in the development of several diseases. Resveratrol is a phenolic compound with antioxidant properties found in fruits such as grapes, berries and peanuts. The purpose of this study was to evaluate the protective effect of Resveratrol in preventing Acrolein-induced toxicity in isolated Mitochondria from the rat liver. Methods: Rat liver Mitochondria were isolated by differential centrifugation. Different concentrations of Acrolein (100 μ M to 2000 μ M) were used to obtain an IC50. Different concentrations of Resveratrol (2. 5 μ M to 40 μ M) were then applied on Mitochondria in the presence of Acrolein toxicity. Results: Acrolein IC50 was obtained via MTT assay as 400 μ M. No toxic effect was observed for Resveratrol and in the presence of Acrolein, there was a significant reduction in Mitochondrial survival even at high concentrations of Resveratrol compared to the control group (P < 0. 001). Conclusions: The results of these study showed that Resveratrol failed to exhibit a protective effect against acute Acrolein toxicity and just because a protective substance could be a marvelous antioxidant does not mean that it can prevent the Mitochondrial damage resulted from any toxicant.

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APA: Copy

SHAFIEI, BEHNAZ, POURAHMAD, JALAL, & REZAEI, MOHSEN. (2019). The Effect of Resveratrol against Acrolein Toxicity in Mitochondria isolated from Rat Liver. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, 11(1 ), 51-57. SID. https://sid.ir/paper/985155/en

Vancouver: Copy

SHAFIEI BEHNAZ, POURAHMAD JALAL, REZAEI MOHSEN. The Effect of Resveratrol against Acrolein Toxicity in Mitochondria isolated from Rat Liver. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;11(1 ):51-57. Available from: https://sid.ir/paper/985155/en

IEEE: Copy

BEHNAZ SHAFIEI, JALAL POURAHMAD, and MOHSEN REZAEI, “The Effect of Resveratrol against Acrolein Toxicity in Mitochondria isolated from Rat Liver,” JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, vol. 11, no. 1 , pp. 51–57, 2019, [Online]. Available: https://sid.ir/paper/985155/en

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