THE STUDY OF SUB-MIC CIPROFLOXACIN EFFECTS ON SHIGELLA DYSENTERIAE

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MOTEVAZE K.; BAMZADEH Z.; MORADI KALBOLANDI SH.

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Journal Paper

Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2008 | Volume:18 | Issue:3 (53) Page(s): 159-165

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Title

THE STUDY OF SUB-MIC CIPROFLOXACIN EFFECTS ON SHIGELLA DYSENTERIAE

Author(s)

MOTEVAZE K. | BAMZADEH Z. | MORADI KALBOLANDI SH. | Issue Writer Certificate

Keywords

SHIGELLA DYSENTERIAEQ2

CIPROFLOXACINQ3

SUB-MICQ3

Abstract

Background: SHIGELLA DYSENTERIAE causes one of the most acute kinds of diarrhea which could be established as chronic infection with alternative periods of recurrence. Administration of normal doses of antibiotics will suppress microbial infections; however it is possible to control these infections by consumption of SUB-MIC doses of certain antibiotics.Materials and methods: In this basic study, a strain of SHIGELLA DYSENTERIAE (PTCC: 1188) was used. After determination of MIC by microdilution method in Muller-Hinton Broth and MBC in Muller-Hinton Agar, the different dilutions (1/2, 1/4, 1/8) of MIC were prepared in order to study the SUB-MIC effects of CIPROFLOXACIN on some traits of SHIGELLA DYSENTERIAE.Results: The results showed that different SUB-MIC dilutions of CIPROFLOXACIN could cause morphological changes in Shigella. The Shigella cells became filamentous in 1/2 MIC whereas this configuration was weaker in 1/4 MIC and 1/8 MIC. Meanwhile, the appearance of colonies was changed significantly due to the higher concentrations of SUB-MIC. Some of the biochemical traits were affected by sub-inhibitory concentrations of CIPROFLOXACIN.Conclusion: CIPROFLOXACIN is a drug of choice for shigellosis. According to the results of this study, treatment of Shigella infections would be possible by lower doses of CIPROFLOXACIN.

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APA: Copy

MOTEVAZE, K., BAMZADEH, Z., & MORADI KALBOLANDI, SH.. (2008). THE STUDY OF SUB-MIC CIPROFLOXACIN EFFECTS ON SHIGELLA DYSENTERIAE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 18(3 (53)), 159-165. SID. https://sid.ir/paper/98562/en

Vancouver: Copy

MOTEVAZE K., BAMZADEH Z., MORADI KALBOLANDI SH.. THE STUDY OF SUB-MIC CIPROFLOXACIN EFFECTS ON SHIGELLA DYSENTERIAE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2008;18(3 (53)):159-165. Available from: https://sid.ir/paper/98562/en

IEEE: Copy

K. MOTEVAZE, Z. BAMZADEH, and SH. MORADI KALBOLANDI, “THE STUDY OF SUB-MIC CIPROFLOXACIN EFFECTS ON SHIGELLA DYSENTERIAE,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 18, no. 3 (53), pp. 159–165, 2008, [Online]. Available: https://sid.ir/paper/98562/en

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