ANTICANCER EFFECTS OF SOME GIRARD-P REAGENT-BASED SCHIFF BASES AND ‎THEIR DIMETHYLTIN (IV) COMPLEXES ON MALIGNANT GLIOBLASTOMA CELL LINE ‎IN IN VITRO CULTURE

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HOVEIZI ELHAM; ANSARI ASL ZEINAB

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Title

ANTICANCER EFFECTS OF SOME GIRARD-P REAGENT-BASED SCHIFF BASES AND ‎THEIR DIMETHYLTIN (IV) COMPLEXES ON MALIGNANT GLIOBLASTOMA CELL LINE ‎IN IN VITRO CULTURE

Author(s)

HOVEIZI ELHAM | ANSARI ASL ZEINAB | Issue Writer Certificate

Keywords

CANCERQ2

SCHIFF BASESQ1

DIMETHYLTIN (IV) COMPLEXESQ1

U-87‎Q1

Abstract

Background: Glioblastoma (U-87) is the most common and most malignant of the glial tumors that ‎appeared in the central nervous system. This is the first study that has evaluated the cytotoxic effects ‎of various Girard-P reagent-based SCHIFF BASES and their dimethyltin (IV) complexes on Glioblastoma ‎cell line, U-87, viability.Materials and methods: In this experimental study, U-87 cell line was grown in DMEM ‎supplemented with 10% FBS, penicillin/streptomycin (100 U/ml, 100 µg/ml) at 37oC in 5% CO2, then ‎the effects of different concentrations of complexes on Glioblastoma cell were evaluated by MTT and ‎DAPI staining.Results: Herein, we demonstrated that these compounds had cytotoxicity effects of Glioblastoma ‎CANCER cells. In a dose dependent manner, a significant cytotoxicity was observed with increasing of ‎P1M and P3.Conclusion: The results showed that Girard-P reagent-based SCHIFF BASES and their dimethyltin (IV) ‎complexes have the ability to induce cytotoxicity in the Glioblastoma CANCER cell line in lower mg/ml ‎concentrations. In conclusion, these findings may introduce a new view on the mode of action and ‎possible application of new compounds in the CANCER chemotherapy.‎ Keywords: CANCER, SCHIFF BASES, Dimethyltin (IV) Complexes, U-87‎.

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APA: Copy

HOVEIZI, ELHAM, & ANSARI ASL, ZEINAB. (2017). ANTICANCER EFFECTS OF SOME GIRARD-P REAGENT-BASED SCHIFF BASES AND ‎THEIR DIMETHYLTIN (IV) COMPLEXES ON MALIGNANT GLIOBLASTOMA CELL LINE ‎IN IN VITRO CULTURE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 27(2), 113-118. SID. https://sid.ir/paper/98577/en

Vancouver: Copy

HOVEIZI ELHAM, ANSARI ASL ZEINAB. ANTICANCER EFFECTS OF SOME GIRARD-P REAGENT-BASED SCHIFF BASES AND ‎THEIR DIMETHYLTIN (IV) COMPLEXES ON MALIGNANT GLIOBLASTOMA CELL LINE ‎IN IN VITRO CULTURE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2017;27(2):113-118. Available from: https://sid.ir/paper/98577/en

IEEE: Copy

ELHAM HOVEIZI, and ZEINAB ANSARI ASL, “ANTICANCER EFFECTS OF SOME GIRARD-P REAGENT-BASED SCHIFF BASES AND ‎THEIR DIMETHYLTIN (IV) COMPLEXES ON MALIGNANT GLIOBLASTOMA CELL LINE ‎IN IN VITRO CULTURE,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 27, no. 2, pp. 113–118, 2017, [Online]. Available: https://sid.ir/paper/98577/en

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