EFFECT OF QUININE ON LATENCY AND AMPLITUDE OF VISUAL EVOKED POTENTIAL P100 PEAK IN MALE MICE

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TORABI NASRIN; SHUSHTARIAN SEYED MOHAMMAD MASOUD; MONAJEMI RAMESH

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2013 | Volume:23 | Issue:3 Page(s): 174-178

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Title

EFFECT OF QUININE ON LATENCY AND AMPLITUDE OF VISUAL EVOKED POTENTIAL P100 PEAK IN MALE MICE

Author(s)

TORABI NASRIN | SHUSHTARIAN SEYED MOHAMMAD MASOUD | MONAJEMI RAMESH | Issue Writer Certificate

Keywords

QUININEQ2

ADVERSE EFFECTSQ3

VISUAL EVOKED POTENTIALQ2

Abstract

Background: QUININE is used for treatment of many disorders, such as malaria and rheumatoid arthritis. Besides good therapeutic effects, it may have multiple ADVERSE EFFECTS. In this study, the effects of QUININE on latency and amplitude in VISUAL EVOKED POTENTIAL (VEP) were evaluated.Materials and Methods: In this experimental study, 50 male Syrian mice were used as control. Five groups of ten mice received doses of 2.5, 12.5, 25, 50, and 62.5 mg of QUININE and one group of ten mice was given 70 mg acetone extract of Cinchona plant intraperitoneally for 14 days. The latency and amplitude of different groups in VEP were recorded.Results: The latency was significantly increased, as parallel as dosage, in 14 days (P<0.05), while the amplitude was significantly decreased, as parallel as dosage, in 14 days (P<0.05).Conclusion: QUININE resulted in significant increase of latency and decrease of amplitude and leaded to visual loss, possibly due to deposition of QUININE on nerve fibers and cone-shaped and cylindrical cells leading to increase in latency phase of transmission from retina to fovea.

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APA: Copy

TORABI, NASRIN, SHUSHTARIAN, SEYED MOHAMMAD MASOUD, & MONAJEMI, RAMESH. (2013). EFFECT OF QUININE ON LATENCY AND AMPLITUDE OF VISUAL EVOKED POTENTIAL P100 PEAK IN MALE MICE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 23(3), 174-178. SID. https://sid.ir/paper/98591/en

Vancouver: Copy

TORABI NASRIN, SHUSHTARIAN SEYED MOHAMMAD MASOUD, MONAJEMI RAMESH. EFFECT OF QUININE ON LATENCY AND AMPLITUDE OF VISUAL EVOKED POTENTIAL P100 PEAK IN MALE MICE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2013;23(3):174-178. Available from: https://sid.ir/paper/98591/en

IEEE: Copy

NASRIN TORABI, SEYED MOHAMMAD MASOUD SHUSHTARIAN, and RAMESH MONAJEMI, “EFFECT OF QUININE ON LATENCY AND AMPLITUDE OF VISUAL EVOKED POTENTIAL P100 PEAK IN MALE MICE,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 23, no. 3, pp. 174–178, 2013, [Online]. Available: https://sid.ir/paper/98591/en

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