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Information Journal Paper

Title

EXPRESSION OF MULTIPLE CANCER/TESTIS GENES IN 32 BREAST CANCER TUMOR SAMPLES

Pages

  179-184

Abstract

 Background: cancer/testis genes (CT-genes) are a family gene which only express in normal testis tissue; some of them are randomly expressed in some types of cancers. The aim of this study was to evaluate the frequency of expression of CT-genes in the patients with BREAST CANCER.Materials and Methods: Thirty two BREAST CANCER tissue samples were prepared. Expression of NY-ESO-1 1a, NY-ESO-1 1b, SCP1, SSX-2 and MAGE-3 genes, as well as GAPDH (internal control), were studied by multiplex RT-PCR method.Results: Three (9%) of 32 tumor samples expressed mRNA of NY-ESO-1 1a, while six (19%) of 32 tumor samples expressed mRNA of NY-ESO-1 1b. Seven (22%) and two (6%) of 32 tumor samples expressed mRNA of SCP1 and mRNA of MAGE3, rtepectively. Overall, Thirteen (41%) samples expressed one of the studied genes.Conclusion: NY-ESO-1 and SCP1 genes had the highest frequency of expression of mRNA. It is suggested that more number of BREAST CANCER tumor samples should be examined to evaluate expression of CT-genes. SCP1 and NY-ESO-1 proteins may promote future BREAST CANCER IMMUNOTHERAPY.

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    APA: Copy

    YOUSEF AMOLI, SHAMSEDDIN, KOKABI, LEYLA, KORDAFSHARI, ALI REZA, ESMAEILI, REZVAN, IZADI, PANTEA, NOROUZNIYA, MEHRDAD, MAJIDZADEH ARDABILI, KEYVAN, & KARIMIPOUR, MORTEZA. (2013). EXPRESSION OF MULTIPLE CANCER/TESTIS GENES IN 32 BREAST CANCER TUMOR SAMPLES. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 23(3), 179-184. SID. https://sid.ir/paper/98594/en

    Vancouver: Copy

    YOUSEF AMOLI SHAMSEDDIN, KOKABI LEYLA, KORDAFSHARI ALI REZA, ESMAEILI REZVAN, IZADI PANTEA, NOROUZNIYA MEHRDAD, MAJIDZADEH ARDABILI KEYVAN, KARIMIPOUR MORTEZA. EXPRESSION OF MULTIPLE CANCER/TESTIS GENES IN 32 BREAST CANCER TUMOR SAMPLES. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2013;23(3):179-184. Available from: https://sid.ir/paper/98594/en

    IEEE: Copy

    SHAMSEDDIN YOUSEF AMOLI, LEYLA KOKABI, ALI REZA KORDAFSHARI, REZVAN ESMAEILI, PANTEA IZADI, MEHRDAD NOROUZNIYA, KEYVAN MAJIDZADEH ARDABILI, and MORTEZA KARIMIPOUR, “EXPRESSION OF MULTIPLE CANCER/TESTIS GENES IN 32 BREAST CANCER TUMOR SAMPLES,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 23, no. 3, pp. 179–184, 2013, [Online]. Available: https://sid.ir/paper/98594/en

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