The effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways gastrocnemius muscle of type 2 diabetic rats

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FAEZI GOLNAZ; SHERAFATI MOGHADAM MOHAMMAD; Shadmehri Saeedeh; FATHALIPOUR MOHAMMAD

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Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2020 | Volume:30 | Issue:2 Page(s): 120-127

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Title

The effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways gastrocnemius muscle of type 2 diabetic rats

Author(s)

FAEZI GOLNAZ | SHERAFATI MOGHADAM MOHAMMAD | Shadmehri Saeedeh | FATHALIPOUR MOHAMMAD | Issue Writer Certificate

Keywords

Gastrocnemius muscle

High-intensity interval training

mTORC1 pathway

Type 2 diabetes

Abstract

Background: The pathway of mTORC1 is one of the most important pathway in protein synthesis, and Type 2 diabetes and insulin resistance can lead to inhibit this pathway. The aim of this study was to investigate the effect of 4 weeks High-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways in Gastrocnemius muscle in type 2 diabetic rats. Materials and methods: In this experimental study, 16 Sprague-Dawley male rats (with mean weight of 250 ±,20 gr) were selected and after induction of diabetes by streptozotocin and nicotinamide, the rats were randomly assigned into two groups, including diabetic HIIT training and diabetic control. The experimental group performed 4 days a week the exercise training for 4 weeks, while the control group did not have any training program. Independent T-test was used to analyze the data. Results: A significant change was not observed in the total content of AKT1 proteins (p<0. 31), P70S6K1 (p<0. 69) and 4EBP1 (p<0. 84) in the HIIT training group compared to the control group, but the total protein content of mTOR (p<0. 02) and the form of phosphorylation of AKT1 (p<0. 03), mTOR (p<0. 03), P70S6K1 (p<0. 02) and 4EBP1 (p<0. 009) proteins showed significant increase in training group compared to the control group. Conclusion: The HIIT training can probably activate the pathway of AKT1/mTOR/P70S6K1 and AKT1/mTOR/4EBP1 in the mTORC1 pathway,therefore, the HIIT training can lead to protein synthesis or muscle hypertrophy through this pathway in the Gastrocnemius muscle of the trained rats.

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APA: Copy

FAEZI, GOLNAZ, SHERAFATI MOGHADAM, MOHAMMAD, Shadmehri, Saeedeh, & FATHALIPOUR, MOHAMMAD. (2020). The effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways gastrocnemius muscle of type 2 diabetic rats. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 30(2 ), 120-127. SID. https://sid.ir/paper/986180/en

Vancouver: Copy

FAEZI GOLNAZ, SHERAFATI MOGHADAM MOHAMMAD, Shadmehri Saeedeh, FATHALIPOUR MOHAMMAD. The effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways gastrocnemius muscle of type 2 diabetic rats. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2020;30(2 ):120-127. Available from: https://sid.ir/paper/986180/en

IEEE: Copy

GOLNAZ FAEZI, MOHAMMAD SHERAFATI MOGHADAM, Saeedeh Shadmehri, and MOHAMMAD FATHALIPOUR, “The effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways gastrocnemius muscle of type 2 diabetic rats,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 30, no. 2 , pp. 120–127, 2020, [Online]. Available: https://sid.ir/paper/986180/en

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