THE EFFECT OF FATIGUE ON PASSIVE AVOIDANCE LEARNING AND ITS INTERACTION WITH SIMVASTATIN DRUG IN MALE WISTAR RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

YAGHMAEI PARICHEHR; HAYATI RUDBARI NASIM; SARKANI FUZIEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2012 | Volume:22 | Issue:3 (69) Page(s): 168-174

Download Full-Text

Persian Verion

View:

743

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF FATIGUE ON PASSIVE AVOIDANCE LEARNING AND ITS INTERACTION WITH SIMVASTATIN DRUG IN MALE WISTAR RATS

Author(s)

YAGHMAEI PARICHEHR | HAYATI RUDBARI NASIM | SARKANI FUZIEH | Issue Writer Certificate

Keywords

FATIGUEQ2

PASSIVE AVOIDANCE LEARNINGQ2

SIMVASTATINQ2

MALE RATQ2

Abstract

Background: The aim of this study was to evaluate the sequence effects of SIMVASTATIN and FATIGUE, specifically the interaction between FATIGUE effects and PASSIVE AVOIDANCE LEARNING in SIMVASTATIN treated rats.Materials and methods: In this experimental study, 40 male Wistar rats weightening 300-350 g were divided into 4 groups: control group: treated with enough tap (n=10), Sham group: rats which were gavaged with distilled water and food (n=10), first experimental (Exp1) and Second experimental (Exp2) group: rats which were gavaged with distilled water and food (n=10) and SIMVASTATIN with dose of 1 mg/kg for 35 days (n=10). Then, both experimental groups were forced to swim in aquariums for 35 days at 9-10 AM to 13-14 PM. At the end of treatment days, PASSIVE AVOIDANCE LEARNING (PAL) system was considered and monitored. The learning and memory of all groups were studied. After performing behavioral tests, testosterone and cortisol were measured.Results: FATIGUE decreased learning activity in Exp group one (P<0.001), while SIMVASTATIN causes increase in learning actitives in Exp group two. Also, FATIGUE induced by forced swimming caused significant decrease of testosterone hormone level (P<0.001), increase of cortisole hormone level (P<0.001) in experimental groups in comparison with sham and control groups.Conclusion: Our study showed that FATIGUE due to long term swimming causes decrease in learning, while SIMVASTATIN drug is effective for prevention of decrease of learning and memory in FATIGUEd rats.

Cites

No record.

References

Cite

APA: Copy

YAGHMAEI, PARICHEHR, HAYATI RUDBARI, NASIM, & SARKANI, FUZIEH. (2012). THE EFFECT OF FATIGUE ON PASSIVE AVOIDANCE LEARNING AND ITS INTERACTION WITH SIMVASTATIN DRUG IN MALE WISTAR RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 22(3 (69)), 168-174. SID. https://sid.ir/paper/98636/en

Vancouver: Copy

YAGHMAEI PARICHEHR, HAYATI RUDBARI NASIM, SARKANI FUZIEH. THE EFFECT OF FATIGUE ON PASSIVE AVOIDANCE LEARNING AND ITS INTERACTION WITH SIMVASTATIN DRUG IN MALE WISTAR RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;22(3 (69)):168-174. Available from: https://sid.ir/paper/98636/en

IEEE: Copy

PARICHEHR YAGHMAEI, NASIM HAYATI RUDBARI, and FUZIEH SARKANI, “THE EFFECT OF FATIGUE ON PASSIVE AVOIDANCE LEARNING AND ITS INTERACTION WITH SIMVASTATIN DRUG IN MALE WISTAR RATS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 22, no. 3 (69), pp. 168–174, 2012, [Online]. Available: https://sid.ir/paper/98636/en

Related Journal Papers