EFFECT OF COMMON PARAOXONASE 1 POLYMORPHISM (Q192R) ON ATHEROSCLEROSIS RISK IN REFERRED DIABETIC PATIENTS TO TABRIZ SHAHID MADANI HEART HOSPITAL IN 2010

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BAYATMAKOO ROSHANAK; MONFAREDAN AMIR; BARGAHI NASRIN; MOBAYEN HAIEDEH; ASLANABADI NASER

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2012 | Volume:22 | Issue:3 (69) Page(s): 191-197

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Title

EFFECT OF COMMON PARAOXONASE 1 POLYMORPHISM (Q192R) ON ATHEROSCLEROSIS RISK IN REFERRED DIABETIC PATIENTS TO TABRIZ SHAHID MADANI HEART HOSPITAL IN 2010

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Keywords

GENETIC POLYMORPHISMQ2

PARAOXONASE1 GENEQ2

ALLELIC ABUNDANCEQ2

Abstract

Background: Paraoxonase is a HDL-associated enzyme implicated in the pathogeneses of atherosclerosis by protecting lipoproteins against peroxidition in numerous studies. Its biallelic gene polymorphism at codon 192Q>R has been associated with coronary artery disease (CAD). Therefore, in the present study the role of polymorphism paraoxonase 1 gene was evaluated for CAD in diabetic patients.Materials and methods: In this case- control study, peripheral blood was taken from 105 CAD patients diagnosed with angioplastically and 95 CAD individuals with no history of diabetes from Northwest of Iranian population. The abundance of mutant alleles of the 192Q>R paraoxonase were determined by PCR-RFLP.Results: The abundance of RR allele in diabetic group was significantly higher than in selected group with no diabetic history (41.1% in diabetic vs.24.5% in non-diabetic individuals).Conclusion: Regarding significant prevalence of RR allele and considering ethnic diversities like Turk, Kurd, Lore and others living in Iran, it appears that other polymorphism of this gene like 163T>A and 55L>M is needed to be studied in diabetic patients, which their relations to atherosclerotic problem has been already determined.

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APA: Copy

BAYATMAKOO, ROSHANAK, MONFAREDAN, AMIR, BARGAHI, NASRIN, MOBAYEN, HAIEDEH, & ASLANABADI, NASER. (2012). EFFECT OF COMMON PARAOXONASE 1 POLYMORPHISM (Q192R) ON ATHEROSCLEROSIS RISK IN REFERRED DIABETIC PATIENTS TO TABRIZ SHAHID MADANI HEART HOSPITAL IN 2010. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 22(3 (69)), 191-197. SID. https://sid.ir/paper/98641/en

Vancouver: Copy

BAYATMAKOO ROSHANAK, MONFAREDAN AMIR, BARGAHI NASRIN, MOBAYEN HAIEDEH, ASLANABADI NASER. EFFECT OF COMMON PARAOXONASE 1 POLYMORPHISM (Q192R) ON ATHEROSCLEROSIS RISK IN REFERRED DIABETIC PATIENTS TO TABRIZ SHAHID MADANI HEART HOSPITAL IN 2010. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;22(3 (69)):191-197. Available from: https://sid.ir/paper/98641/en

IEEE: Copy

ROSHANAK BAYATMAKOO, AMIR MONFAREDAN, NASRIN BARGAHI, HAIEDEH MOBAYEN, and NASER ASLANABADI, “EFFECT OF COMMON PARAOXONASE 1 POLYMORPHISM (Q192R) ON ATHEROSCLEROSIS RISK IN REFERRED DIABETIC PATIENTS TO TABRIZ SHAHID MADANI HEART HOSPITAL IN 2010,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 22, no. 3 (69), pp. 191–197, 2012, [Online]. Available: https://sid.ir/paper/98641/en

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