ASSOCIATION OF MIR-196A2 (RS11614913) POLYMORPHISM WITH COLORECTAL CANCER IN TEHRAN POPULATION

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MIRTALEBI HANIE; HEYDARI NASRABADI MITRA; POURHOSEINGHOLI MOHAMAD AMIN; ASADZADEH AGHDAEI HAMID

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2014 | Volume:23 | Issue:1 (SUPP.) Page(s): 11-15

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Title

ASSOCIATION OF MIR-196A2 (RS11614913) POLYMORPHISM WITH COLORECTAL CANCER IN TEHRAN POPULATION

Author(s)

MIRTALEBI HANIE | HEYDARI NASRABADI MITRA | POURHOSEINGHOLI MOHAMAD AMIN | ASADZADEH AGHDAEI HAMID | Issue Writer Certificate

Keywords

POLYMORPHISMQ2

MICRORNAQ1

COLORECTAL CANCERQ2

Abstract

Background: Micro RNAs (miRNAs) are identified agents for post-transcriptional regulation of gene expression and miRNA POLYMORPHISMs are recognized as useful biomarkers for prognosis of COLORECTAL CANCER. The association of rs 11614913 POLYMORPHISM in miR-196a2 gene and the risk of COLORECTAL CANCER were investigated in this study.Materials and Methods: I this case- control study, 149 patients with COLORECTAL CANCER and 146 healthy subjects whom referred to Taleghani hospital, Tehran were studied. Polymerase chain reaction- restriction fragment length POLYMORPHISM (PCR-RFLP) method was used for genotyping.Results: The frequency of CT, TT and CC genotypes in control group were 40%, 24% and 36%, respectively. Moreover, genotype frequencies in case group were revealed as 49% for CT, 10% for TT and 41 % for CC. The frequencies of C and T alleles in control group were 48% and 70%, and 42% and 30% in case group, respectively. Among all genotypes, an association between CRC risk and TT genotype was determined in our survey (OR=0.4, 95%CI= 0.17-0.92; p=0.03).Conclusion: This study showed that modified miR-196a2 sequence affects MICRORNA efficiency which may have an impact on COLORECTAL CANCER susceptibility.

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APA: Copy

MIRTALEBI, HANIE, HEYDARI NASRABADI, MITRA, POURHOSEINGHOLI, MOHAMAD AMIN, & ASADZADEH AGHDAEI, HAMID. (2014). ASSOCIATION OF MIR-196A2 (RS11614913) POLYMORPHISM WITH COLORECTAL CANCER IN TEHRAN POPULATION. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 23(1 (SUPP.)), 11-15. SID. https://sid.ir/paper/98501/en

Vancouver: Copy

MIRTALEBI HANIE, HEYDARI NASRABADI MITRA, POURHOSEINGHOLI MOHAMAD AMIN, ASADZADEH AGHDAEI HAMID. ASSOCIATION OF MIR-196A2 (RS11614913) POLYMORPHISM WITH COLORECTAL CANCER IN TEHRAN POPULATION. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2014;23(1 (SUPP.)):11-15. Available from: https://sid.ir/paper/98501/en

IEEE: Copy

HANIE MIRTALEBI, MITRA HEYDARI NASRABADI, MOHAMAD AMIN POURHOSEINGHOLI, and HAMID ASADZADEH AGHDAEI, “ASSOCIATION OF MIR-196A2 (RS11614913) POLYMORPHISM WITH COLORECTAL CANCER IN TEHRAN POPULATION,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 23, no. 1 (SUPP.), pp. 11–15, 2014, [Online]. Available: https://sid.ir/paper/98501/en

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