EFFECTS OF LOSARTAN ON SPATIAL MEMORY DEFICITS INDUCED BY GLOBAL ISCHEMIA / REPERFUSION IN MALE WISTAR RATS

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MOVASSAGHI SHIMA; MOVASSAGHI SHABNAM; YOUSEFI OUDARJI ALI; NADIA SHARIFI ZAHRA

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2017 | Volume:27 | Issue:3 Page(s): 187-193

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Title

EFFECTS OF LOSARTAN ON SPATIAL MEMORY DEFICITS INDUCED BY GLOBAL ISCHEMIA / REPERFUSION IN MALE WISTAR RATS

Author(s)

MOVASSAGHI SHIMA | MOVASSAGHI SHABNAM | YOUSEFI OUDARJI ALI | NADIA SHARIFI ZAHRA | Issue Writer Certificate

Keywords

CEREBRAL ISCHEMIAQ2

LOSARTANQ3

SPATIAL MEMORYQ2

NEUROPROTECTIVEQ2

Abstract

Background: Stroke is the most important reason of CEREBRAL ISCHEMIA and following reperfusion lead to programmed cell death. Harm to hippocampus causes major disruption in the performance of active memory tests. So in this study, we investigated the effect of LOSARTAN (angiotensin antagonists II) on SPATIAL MEMORY deficits and neuronal damage caused by ischemia /reperfusion in rats. Materials and methods: In this experimental study, animals were divided into 4 groups as follow: control, ischemia, experimental and vehicle. 20 minutes before ischemia, 5mg/kg LOSARTAN was injected to animals in experimental group. Ischemia was done by both common carotid occlusion for 20 minutes followed by reperfusion. After a week, rats were tested by Morris water maze and histological changes of CA1 pyramidal cells were studied by Nissl and Tunnel staining. Results: Results of Morris water maze showed significant difference between control and ischemia groups, while this difference was not significant between control and experimental groups. There was significant difference in the number of viable pyramidal neurons and apoptotic cells in CA1 region of hippocampus between control and experimental groups compared with vehicle and ischemia groups. Conclusion: 5mg/kg LOSARTAN improves pyramidal cells and histological changes of CA1 region caused by ischemia/ reperfusion and can prevent apoptosis, but this dose cannot reduce behavioral disorders caused by CEREBRAL ISCHEMIA.

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APA: Copy

MOVASSAGHI, SHIMA, MOVASSAGHI, SHABNAM, YOUSEFI OUDARJI, ALI, & NADIA SHARIFI, ZAHRA. (2017). EFFECTS OF LOSARTAN ON SPATIAL MEMORY DEFICITS INDUCED BY GLOBAL ISCHEMIA / REPERFUSION IN MALE WISTAR RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 27(3), 187-193. SID. https://sid.ir/paper/98651/en

Vancouver: Copy

MOVASSAGHI SHIMA, MOVASSAGHI SHABNAM, YOUSEFI OUDARJI ALI, NADIA SHARIFI ZAHRA. EFFECTS OF LOSARTAN ON SPATIAL MEMORY DEFICITS INDUCED BY GLOBAL ISCHEMIA / REPERFUSION IN MALE WISTAR RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2017;27(3):187-193. Available from: https://sid.ir/paper/98651/en

IEEE: Copy

SHIMA MOVASSAGHI, SHABNAM MOVASSAGHI, ALI YOUSEFI OUDARJI, and ZAHRA NADIA SHARIFI, “EFFECTS OF LOSARTAN ON SPATIAL MEMORY DEFICITS INDUCED BY GLOBAL ISCHEMIA / REPERFUSION IN MALE WISTAR RATS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 27, no. 3, pp. 187–193, 2017, [Online]. Available: https://sid.ir/paper/98651/en

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