THE EFFECT OF PENTOXIFYLLINE ON GLOBAL ISCHEMIA/REPERFUSION INDUCED SPATIAL MEMORY IMPAIRMENT IN ESTROUS PHASE OF FEMALE WISTAR RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

PANAHI KHEZRI NOOSHIN; NADIA SHARIFI ZAHRA; SHAFAROODI HAMED; ANSARIAN GHAZAL; MOVASSAGHI SHABNAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2014 | Volume:24 | Issue:1 Page(s): 14-21

Download Full-Text

Persian Verion

View:

766

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF PENTOXIFYLLINE ON GLOBAL ISCHEMIA/REPERFUSION INDUCED SPATIAL MEMORY IMPAIRMENT IN ESTROUS PHASE OF FEMALE WISTAR RAT

Author(s)

Keywords

PENTOXIFYLLINEQ2

SPATIAL MEMORYQ2

BRAIN ISCHEMIAQ2

ESTROGENQ2

Abstract

Background: The short break in cerebral blood flow causes permanent brain injury and behavioral dysfunction. The hippocampus, specifically the CA1 pyramidal cells, is highly vulnerable to ischemic injuries. There is no effective pharmacological strategy for improving brain tissue damage induced by cerebral ischemia. Previous studies reported that PENTOXIFYLLINE has a neuroprotective effect on brain trauma and it is well known that endogenous ESTROGEN improves stroke outcome during vascular occlusion. In this study, the possible positive effects of PENTOXIFYLLINE and ESTROGEN on behavioral deficit and neuronal damage were studied in female Wistar rats in estrous phase subjected to an experimental model of transient global BRAIN ISCHEMIA. Materials and methods: In this experimental study, female Wistar rats (n=56) were assigned to control, ischemia, vehicle, and PENTOXIFYLLINE - treated (200 mg/kg IP) groups and all of them were in their estrous phase. PENTOXIFYLLINE was administered at 1 h before and 1 h after ischemia. Global cerebral ischemia was induced by bilateral common carotid artery occlusion, followed by reperfusion. Morris water maze and nissl staining was used for all groups.Results: According to Morris water maze test results, cerebral ischemia could not exert any negative effect on cognitive spatial abilities after reperfusion and there were no significant differences between groups. In Nissl study, there were significant differences between number of pyramidal cells in both control and PENTOXIFYLLINE - treated groups (P£0.05), either ischemia and vehicle groups.Conclusion: Our study illustrated that PENTOXIFYLLINE can reduce CA1 cell damages and in presence of ESTROGEN prevents any cognitive impairment in female rats which were subjected to brain global ischemia.

Cites

No record.

References

Cite

APA: Copy

PANAHI KHEZRI, NOOSHIN, NADIA SHARIFI, ZAHRA, SHAFAROODI, HAMED, ANSARIAN, GHAZAL, & MOVASSAGHI, SHABNAM. (2014). THE EFFECT OF PENTOXIFYLLINE ON GLOBAL ISCHEMIA/REPERFUSION INDUCED SPATIAL MEMORY IMPAIRMENT IN ESTROUS PHASE OF FEMALE WISTAR RAT. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 24(1), 14-21. SID. https://sid.ir/paper/98943/en

Vancouver: Copy

PANAHI KHEZRI NOOSHIN, NADIA SHARIFI ZAHRA, SHAFAROODI HAMED, ANSARIAN GHAZAL, MOVASSAGHI SHABNAM. THE EFFECT OF PENTOXIFYLLINE ON GLOBAL ISCHEMIA/REPERFUSION INDUCED SPATIAL MEMORY IMPAIRMENT IN ESTROUS PHASE OF FEMALE WISTAR RAT. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2014;24(1):14-21. Available from: https://sid.ir/paper/98943/en

IEEE: Copy

NOOSHIN PANAHI KHEZRI, ZAHRA NADIA SHARIFI, HAMED SHAFAROODI, GHAZAL ANSARIAN, and SHABNAM MOVASSAGHI, “THE EFFECT OF PENTOXIFYLLINE ON GLOBAL ISCHEMIA/REPERFUSION INDUCED SPATIAL MEMORY IMPAIRMENT IN ESTROUS PHASE OF FEMALE WISTAR RAT,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 24, no. 1, pp. 14–21, 2014, [Online]. Available: https://sid.ir/paper/98943/en

Related Journal Papers