NOD2 NOVEL MUTATIONS IN IRANIAN CROHN'S PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FARNOOD ALMA; NADERI NOSRATOLLAH; HABIBI MANIJEH; BALAIE HEDIEH; ZOJAJI HOMAYOUN; FIROUZI FARZAD; CHIANI MOHSEN; DERAKHSHAN FARAMARZ; AGHAZADEH RAHIM; EBRAHIMI DARYANI NASER; ZALI MOHAMMAD REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2011 | Volume:20 | Issue:4 Page(s): 235-240

Download Full-Text

Persian Verion

View:

869

Download:

Cites:

Information Journal Paper

Title

NOD2 NOVEL MUTATIONS IN IRANIAN CROHN'S PATIENTS

Author(s)

Keywords

NOD2Q2

CROHN’SQ3

MUTATIONQ2

Abstract

Background: Despite the reported role of three common MUTATIONs of the CARD15/NOD2 gene including R702W, G908R and 1007fs in CROHN’S disease (CD), only about 30% of Iranian CD patients carry one of these three variants (R702W). The aim of this study was to screen the hot points of NOD2 gene to find any novel sequence variations in Iranian patients with CD.Materials and methods: Eighty non-related Crohn's patients from Iranian origin, referred to a tertiary center in a three-year period (2006-2009), were enrolled in this study. The hot points of NOD2 gene (including exons 4 and 8) were evaluated by direct sequencing after amplification of related sequences with polymerase chain reaction (PCR).Results: A total of 17 sequence variations were identified among these exons of NOD2 gene including 7 novel ones. Three of these new MUTATIONs had an allele frequency more than 5%. All new MUTATIONs were a consequence of a single nucleotide change, 4 resulted in an aminoacid change while one formed a stop coden. No deletion or insertion MUTATION was observed in this part of the gene.Conclusion: This study demonstrated the existence of uncommon NOD2 variants in Iranian patients with CD. It is possible that these MUTATIONs play a role in susceptibility to CD in Iranian population.

Cites

No record.

References

No record.

Cite

APA: Copy

FARNOOD, ALMA, NADERI, NOSRATOLLAH, HABIBI, MANIJEH, BALAIE, HEDIEH, ZOJAJI, HOMAYOUN, FIROUZI, FARZAD, CHIANI, MOHSEN, DERAKHSHAN, FARAMARZ, AGHAZADEH, RAHIM, EBRAHIMI DARYANI, NASER, & ZALI, MOHAMMAD REZA. (2011). NOD2 NOVEL MUTATIONS IN IRANIAN CROHN'S PATIENTS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 20(4), 235-240. SID. https://sid.ir/paper/98692/en

Vancouver: Copy

FARNOOD ALMA, NADERI NOSRATOLLAH, HABIBI MANIJEH, BALAIE HEDIEH, ZOJAJI HOMAYOUN, FIROUZI FARZAD, CHIANI MOHSEN, DERAKHSHAN FARAMARZ, AGHAZADEH RAHIM, EBRAHIMI DARYANI NASER, ZALI MOHAMMAD REZA. NOD2 NOVEL MUTATIONS IN IRANIAN CROHN'S PATIENTS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2011;20(4):235-240. Available from: https://sid.ir/paper/98692/en

IEEE: Copy

ALMA FARNOOD, NOSRATOLLAH NADERI, MANIJEH HABIBI, HEDIEH BALAIE, HOMAYOUN ZOJAJI, FARZAD FIROUZI, MOHSEN CHIANI, FARAMARZ DERAKHSHAN, RAHIM AGHAZADEH, NASER EBRAHIMI DARYANI, and MOHAMMAD REZA ZALI, “NOD2 NOVEL MUTATIONS IN IRANIAN CROHN'S PATIENTS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 20, no. 4, pp. 235–240, 2011, [Online]. Available: https://sid.ir/paper/98692/en

Related Journal Papers