THE EFFECT OF STATINS ON PASSIVE AVOIDANCE LEARNING AND NEUROGENESIS IN HIPPOCAMPAL CA1 AND DG REGIONS IN NBM-LESIONED WISTAR RATS

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YAGHMAEI PARICHEHR; PARIVAR KAZEM; ALIKHANI NASIM

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2012 | Volume:22 | Issue:2 Page(s): 85-92

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Title

THE EFFECT OF STATINS ON PASSIVE AVOIDANCE LEARNING AND NEUROGENESIS IN HIPPOCAMPAL CA1 AND DG REGIONS IN NBM-LESIONED WISTAR RATS

Author(s)

YAGHMAEI PARICHEHR | PARIVAR KAZEM | ALIKHANI NASIM | Issue Writer Certificate

Keywords

ALZHEIMER'S DISEASEQ2

STATINSQ2

PASSIVE AVOIDANCE LEARNINGQ2

HYPOCAMPQ2

MALE RATQ2

Abstract

Background: ALZHEIMER'S DISEASE (AD) is a progressive neurodegenerative, age-related disease characterized by dementia and the loss of neuronal cells in the brain.Materials and Methods: In this experimental study, the male wistar rat were studied in five groups: control group: intact rat, sham group: NBM destructed rats by ibotenic acid and receiving salin for 14 days via gavage, experimental groups 1, 2 and 3: rat with destructed NBM and receiving 1mg/kg, simvastatin 1mg/kg, and atorvastatin and simvastatin each 0.5mg/kg via gavage, respectively, for 14 days. Learning and memory of all groups were examined by the shuttle box. In order to histological surveys, the brain were removed completely and transferred to formalin 10%.Results: STL (duration of stay in the clear) was significantly increased in the experimental groups compared with control and sham groups (P<0.001).Statin caused significant decreasing (P<0.001) of TDC (duration of stay in the dark) in the experimental groups in comparison of control and sham groups.Histological studies of brain showed significant increasing of the granular cell in the DG area and also the significant increasing of the pyramidal cell CA1 area in group 2 (P<0.001) and group 3 (P<0.01).Conclusion: This study showed that STATINS may result in improving learning and memory and repair of hypo camp in male Alzheimer rats.

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APA: Copy

YAGHMAEI, PARICHEHR, PARIVAR, KAZEM, & ALIKHANI, NASIM. (2012). THE EFFECT OF STATINS ON PASSIVE AVOIDANCE LEARNING AND NEUROGENESIS IN HIPPOCAMPAL CA1 AND DG REGIONS IN NBM-LESIONED WISTAR RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 22(2), 85-92. SID. https://sid.ir/paper/98724/en

Vancouver: Copy

YAGHMAEI PARICHEHR, PARIVAR KAZEM, ALIKHANI NASIM. THE EFFECT OF STATINS ON PASSIVE AVOIDANCE LEARNING AND NEUROGENESIS IN HIPPOCAMPAL CA1 AND DG REGIONS IN NBM-LESIONED WISTAR RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;22(2):85-92. Available from: https://sid.ir/paper/98724/en

IEEE: Copy

PARICHEHR YAGHMAEI, KAZEM PARIVAR, and NASIM ALIKHANI, “THE EFFECT OF STATINS ON PASSIVE AVOIDANCE LEARNING AND NEUROGENESIS IN HIPPOCAMPAL CA1 AND DG REGIONS IN NBM-LESIONED WISTAR RATS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 22, no. 2, pp. 85–92, 2012, [Online]. Available: https://sid.ir/paper/98724/en

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