ANALYSIS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS) GENE POLYMORPHISM GLU 298 ASP AS A RISK FACTOR OF CORONARY ARTERY DISEASE IN A SAMPLE OF IRANIAN POPULATION

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REJALI LEILI; HASANZAD MANDANA; NAJAFI ALIREZA; MOHAMMAD HASSANI MOHAMAD REZA; FATHI MEYMANAT; SARZAEIM MOHAMMAD REZD; JAMALEDINI SEYED HAMID; SAMZADEH MOHAMMAD

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2012 | Volume:22 | Issue:2 Page(s): 116-121

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Title

ANALYSIS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS) GENE POLYMORPHISM GLU 298 ASP AS A RISK FACTOR OF CORONARY ARTERY DISEASE IN A SAMPLE OF IRANIAN POPULATION

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Keywords

CORONARY ARTERY DISEASEQ2

ENDOTHELIAL NITRIC OXIDE SYNTHASEQ2

GENETIC POLYMORPHISMQ2

Abstract

Background: Genetic factors contribute to the pathogenesis of CORONARY ARTERY DISEASE (CAD). Among many polymorphisms of the eNOS gene, the Glu298Asp variant has implications in CORONARY ARTERY DISEASE (CAD). The aim of the present study was to investigate the association between CAD risk and Glu298Asp polymorphism of the eNOS gene.Materials and Methods: In this case- control study, the eNOS gene polymorphism was analyzed in 92 Iranian patients with CORONARY ARTERY DISEASE and 93control subjects. The Glu298Asp polymorphism of the ENDOTHELIAL NITRIC OXIDE SYNTHASE gene was determined by polymerase chain reaction and restriction fragment length polymorphism.Results: There were significant differences between the control and patient groups for the eNOS3 genotypes. In addition, the family history of CORONARY ARTERY DISEASE, hypertension, dyslipidemia and eNOS TT genotype were independent risk factors of CORONARY ARTERY DISEASE. Those with TT genotypes hd 3.5 times (odds ratio=3.57) risk of CORONARY ARTERY DISEASE compared with the control group.Conclusion: These results suggest that CORONARY ARTERY DISEASE is associated with the Glu298Asp polymorphism of the ENDOTHELIAL NITRIC OXIDE SYNTHASE gene in our population.

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APA: Copy

REJALI, LEILI, HASANZAD, MANDANA, NAJAFI, ALIREZA, MOHAMMAD HASSANI, MOHAMAD REZA, FATHI, MEYMANAT, SARZAEIM, MOHAMMAD REZD, JAMALEDINI, SEYED HAMID, & SAMZADEH, MOHAMMAD. (2012). ANALYSIS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS) GENE POLYMORPHISM GLU 298 ASP AS A RISK FACTOR OF CORONARY ARTERY DISEASE IN A SAMPLE OF IRANIAN POPULATION. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 22(2), 116-121. SID. https://sid.ir/paper/98725/en

Vancouver: Copy

REJALI LEILI, HASANZAD MANDANA, NAJAFI ALIREZA, MOHAMMAD HASSANI MOHAMAD REZA, FATHI MEYMANAT, SARZAEIM MOHAMMAD REZD, JAMALEDINI SEYED HAMID, SAMZADEH MOHAMMAD. ANALYSIS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS) GENE POLYMORPHISM GLU 298 ASP AS A RISK FACTOR OF CORONARY ARTERY DISEASE IN A SAMPLE OF IRANIAN POPULATION. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;22(2):116-121. Available from: https://sid.ir/paper/98725/en

IEEE: Copy

LEILI REJALI, MANDANA HASANZAD, ALIREZA NAJAFI, MOHAMAD REZA MOHAMMAD HASSANI, MEYMANAT FATHI, MOHAMMAD REZD SARZAEIM, SEYED HAMID JAMALEDINI, and MOHAMMAD SAMZADEH, “ANALYSIS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS) GENE POLYMORPHISM GLU 298 ASP AS A RISK FACTOR OF CORONARY ARTERY DISEASE IN A SAMPLE OF IRANIAN POPULATION,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 22, no. 2, pp. 116–121, 2012, [Online]. Available: https://sid.ir/paper/98725/en

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