PLASMA FREE 8-ISO-PGF2α LEVELS IN NORMOTENSIVE AND PREECLAMPTIC PREGNANCIES

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SEYFI FARINAZ; MAHDIZADEH A.A.F.; NOURMOHAMMADI I.

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2009 | Volume:19 | Issue:1 (55) Page(s): 49-53

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Title

PLASMA FREE 8-ISO-PGF2α LEVELS IN NORMOTENSIVE AND PREECLAMPTIC PREGNANCIES

Author(s)

SEYFI FARINAZ | MAHDIZADEH A.A.F. | NOURMOHAMMADI I. | Issue Writer Certificate

Keywords

FREE 8-ISO-PGF2αQ3

PREGNANCYQ3

PREECLAMPSIAQ2

Abstract

Background: PREECLAMPSIA is a main cause of morbidity and mortality of pregnant women worldwide. Recently oxidative stress was considered as a part of pathophysiolgy of preeclamsia and 8-iso-prostaglandin F2a (8-iso-PGF2a) is known as a marker of oxidative stress. The purpose of this study was to measure and compare plasma concentration of free 8-iso-PG F2a in women with normotensive and preeclamptic pregnancies.Materials and methods: In this descriptive-analytic study, Plasma free 8-iso-PGF2a levels were measured in pregnant women with preeclamsia (n=42) and normotensive pregnant women (n=39) between 28-38 weeks of gestation. Women in two groups were matched in age, gestational age and socioeconomic status and all women were nulligravid.Results: Free 8-iso-PGF2a levels were not significantly different in women with preeclamsia and normotensive group (17808 vs. 24288 pg/dl, NS). Plasma free 8-iso-PGF2a levels were increased in severe compared to mild PREECLAMPSIA (NS). Neonates weight of preeclamptic mothers was significantly lower than neonates of normotensive women (p<0.0001).Conclusion: Although free 8-iso-PGF2a is a marker of oxidative stress in vitro, but its measurement is not valuable in clinical medicine. However, further studies in normal PREGNANCY and PREECLAMPSIA will be needed.

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APA: Copy

SEYFI, FARINAZ, MAHDIZADEH, A.A.F., & NOURMOHAMMADI, I.. (2009). PLASMA FREE 8-ISO-PGF2α LEVELS IN NORMOTENSIVE AND PREECLAMPTIC PREGNANCIES. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 19(1 (55)), 49-53. SID. https://sid.ir/paper/98757/en

Vancouver: Copy

SEYFI FARINAZ, MAHDIZADEH A.A.F., NOURMOHAMMADI I.. PLASMA FREE 8-ISO-PGF2α LEVELS IN NORMOTENSIVE AND PREECLAMPTIC PREGNANCIES. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2009;19(1 (55)):49-53. Available from: https://sid.ir/paper/98757/en

IEEE: Copy

FARINAZ SEYFI, A.A.F. MAHDIZADEH, and I. NOURMOHAMMADI, “PLASMA FREE 8-ISO-PGF2α LEVELS IN NORMOTENSIVE AND PREECLAMPTIC PREGNANCIES,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 19, no. 1 (55), pp. 49–53, 2009, [Online]. Available: https://sid.ir/paper/98757/en

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