Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury

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FOOLADI MASOOMEH; Cheki Mohsen; SHIRAZI ALIREZA; Sheikhzadeh Peyman; Amirrashedi Mahsa; GHAHRAMANI FATEMEH; KHOOBI MEHDI

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Journal: JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING Year:2022 | Volume:12 | Issue:3 Page(s): 277-284

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Title

Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury

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Keywords

Radiation

Ionizing

Radioprotector

Bone Marrow

Telmisartan

Abstract

Background: Radiation-induced hematopoietic suppression and myelotoxicity can occur due to the nuclear accidents, occupational irradiation and therapeutic interventions. Bone marrow dysfunction has always been one of the most important causes of morbidity and mortality after ionizing irradiation. Objective: This study aims to investigate the protective effect of telmisartan against radiation-induced bone marrow injuries in a Balb/c mouse model. Material and Methods: In this experimental study, male Balb/c mice were divided into four groups as follow: group 1: mice received phosphate buffered saline (PBS) without irradiation, group 2: mice received a solution of telmisartan in PBS without irradiation, group 3: mice received PBS with irradiation, and group 4: mice received a solution of telmisartan in PBS with irradiation. A solution of telmisartan was prepared and administered orally at 12 mg/kg body weight for seven consecutive days prior to whole body exposing to a single sub-lethal dose of 5 Gy X-rays. Protection of bone marrow against radiation induced damage was investigated by Hematoxylin-Eosin (HE) staining assay at 3, 9, 15 and 30 days after irradiation. Results: Histopathological analysis indicated that administration of telmisartan reduced X-radiation-induced damage and improved bone marrow histology. The number of different cell types in bone marrow, including polymorphonuclear /mononuclear cells and megakaryocytes significantly increased in telmisartan treated group compared to the only irradiated group at all-time points. Conclusion: The results of the present study demonstrated an efficient radioprotective effect of telmisartan in mouse bone marrow against sub-lethal X-irradiation.

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APA: Copy

FOOLADI, MASOOMEH, Cheki, Mohsen, SHIRAZI, ALIREZA, Sheikhzadeh, Peyman, Amirrashedi, Mahsa, GHAHRAMANI, FATEMEH, & KHOOBI, MEHDI. (2022). Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury. JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING, 12(3), 277-284. SID. https://sid.ir/paper/987777/en

Vancouver: Copy

FOOLADI MASOOMEH, Cheki Mohsen, SHIRAZI ALIREZA, Sheikhzadeh Peyman, Amirrashedi Mahsa, GHAHRAMANI FATEMEH, KHOOBI MEHDI. Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury. JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING[Internet]. 2022;12(3):277-284. Available from: https://sid.ir/paper/987777/en

IEEE: Copy

MASOOMEH FOOLADI, Mohsen Cheki, ALIREZA SHIRAZI, Peyman Sheikhzadeh, Mahsa Amirrashedi, FATEMEH GHAHRAMANI, and MEHDI KHOOBI, “Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury,” JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING, vol. 12, no. 3, pp. 277–284, 2022, [Online]. Available: https://sid.ir/paper/987777/en

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