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Information Journal Paper

Title

Analysis of Single Nucleotide Polymorphisms in HLA-DRA, IL2RA, and HMGB1 Genes in Multiple Sclerosis

Pages

  199-208

Abstract

 Background: Multiple sclerosis (MS) is a common demyelinating neurodegenerative disorder with significant heritability. Previous studies have associated genetic variants in human leukocyte antigen (HLA) complex, IL2RA, and HMGB1 genes with the pathophysiology of MS. Methods: In order to investigate the gene association in the Iranian population, we performed a genotyping study of 36 variants in the mentioned genes using Sanger sequencing in 102 MS patients and 113 healthy controls. Results: Our results identified significant associations as well as significant allele frequency differences in some of the studied single-nucleotide Polymorphisms including rs4935356, rs3177928, and rs7197 from HLA-DRA gene, and rs12722489 and rs12722490 variants from IL2RA gene (p< 0. 05). Moreover, the strong linkage disequilibrium of two common haplotypes was estimated from the HLA-DRA gene. Conclusions: This association study may suggest the role of these Polymorphisms in the genetic susceptibility of MS in the Iranian population and would facilitate the recognition of causative variants in this disease.

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    APA: Copy

    Asouri, Mohsen, Alinejad Rokni, Hamid, SAHRAIAN, MOHAMMAD ALI, FATTAHI, SADEGH, MOTAMED, NIMA, Doosti, Rozita, RAHIMI, HAMZEH, LOTFI, MARYAM, MOSLEMI, AZAM, Karimpoor, Morteza, MAHBOUDI, FEREIDOUN, & AKHAVAN NIAKI, HALEH. (2020). Analysis of Single Nucleotide Polymorphisms in HLA-DRA, IL2RA, and HMGB1 Genes in Multiple Sclerosis. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 9(2), 199-208. SID. https://sid.ir/paper/988366/en

    Vancouver: Copy

    Asouri Mohsen, Alinejad Rokni Hamid, SAHRAIAN MOHAMMAD ALI, FATTAHI SADEGH, MOTAMED NIMA, Doosti Rozita, RAHIMI HAMZEH, LOTFI MARYAM, MOSLEMI AZAM, Karimpoor Morteza, MAHBOUDI FEREIDOUN, AKHAVAN NIAKI HALEH. Analysis of Single Nucleotide Polymorphisms in HLA-DRA, IL2RA, and HMGB1 Genes in Multiple Sclerosis. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2020;9(2):199-208. Available from: https://sid.ir/paper/988366/en

    IEEE: Copy

    Mohsen Asouri, Hamid Alinejad Rokni, MOHAMMAD ALI SAHRAIAN, SADEGH FATTAHI, NIMA MOTAMED, Rozita Doosti, HAMZEH RAHIMI, MARYAM LOTFI, AZAM MOSLEMI, Morteza Karimpoor, FEREIDOUN MAHBOUDI, and HALEH AKHAVAN NIAKI, “Analysis of Single Nucleotide Polymorphisms in HLA-DRA, IL2RA, and HMGB1 Genes in Multiple Sclerosis,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 9, no. 2, pp. 199–208, 2020, [Online]. Available: https://sid.ir/paper/988366/en

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