The Evaluation of Antibiotic Resistance and nalB Mutants in Pseudomonas aeruginosa Isolated from Burnt Patients of Shohada Mehrab Yazd Hospital Burn Ward

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Moosavi Seyed Morteza; Pouresmaeil Omid; ZANDI HENGAMEH; Emadi Sahar; Akhavan Fatemeh; TORKI ALIREZA; ASTANI AKRAM

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Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2020 | Volume:9 | Issue:2 Page(s): 140-146

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Title

The Evaluation of Antibiotic Resistance and nalB Mutants in Pseudomonas aeruginosa Isolated from Burnt Patients of Shohada Mehrab Yazd Hospital Burn Ward

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Keywords

Antibiotic Resistance

Burn Infections

Hospital-Acquired Infections

Nosocomial Infections

Pseudomonas aeruginosa

Abstract

Background: Due to extensive damage to the skin, burn victims may acquire life-threatening infections. Though the skin primarily protects against microbial invasions, a large number of bacteria, fungi, and viruses can be isolated from burn patients, specifically Pseudomonas aeruginosa, a gram-negative bacterium with both intrinsic and acquired Antibiotic Resistance (AR) properties. nalB mutations can be found on the mexR in the P. aeruginosa chromosome. This mutation can induce overexpression of the mexAB-oprMoperon, and affect the MexAB-OprM efflux pump, which removes antimicrobial agents from the bacterial cell. Identifying nalB mutants can be useful for monitoring factors affecting AR. Methods: In this study, 70 P. aeruginosa isolates identified from burn patients and antibacterial sensitivity was evaluated using the Kirby-Bauer method. We also investigated nalB mutations in samples using molecular methods including Polymerase reaction chain (PCR) and Sequencing. Results: We identified nalB mutations in 16 isolates. We also found that the increasing effect of nalB mutants induces hyper production activity of MexAB-OprM resulting in AR. Overall, these findings compliment the findings of previous reports. Conclusions: According to the resistance patterns of the samples, both Amikacin and Ciprofloxacin showed the highest resistance (%). Further, the relationship between Ciprofloxacin resistance and nalB mutations was statistically significant (p= 0. 016). The results confirm that the increasing effect of nalB mutants on hyper production activity of MexAB-OprM leads to AR.

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APA: Copy

Moosavi, Seyed Morteza, Pouresmaeil, Omid, ZANDI, HENGAMEH, Emadi, Sahar, Akhavan, Fatemeh, TORKI, ALIREZA, & ASTANI, AKRAM. (2020). The Evaluation of Antibiotic Resistance and nalB Mutants in Pseudomonas aeruginosa Isolated from Burnt Patients of Shohada Mehrab Yazd Hospital Burn Ward. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 9(2), 140-146. SID. https://sid.ir/paper/988515/en

Vancouver: Copy

Moosavi Seyed Morteza, Pouresmaeil Omid, ZANDI HENGAMEH, Emadi Sahar, Akhavan Fatemeh, TORKI ALIREZA, ASTANI AKRAM. The Evaluation of Antibiotic Resistance and nalB Mutants in Pseudomonas aeruginosa Isolated from Burnt Patients of Shohada Mehrab Yazd Hospital Burn Ward. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2020;9(2):140-146. Available from: https://sid.ir/paper/988515/en

IEEE: Copy

Seyed Morteza Moosavi, Omid Pouresmaeil, HENGAMEH ZANDI, Sahar Emadi, Fatemeh Akhavan, ALIREZA TORKI, and AKRAM ASTANI, “The Evaluation of Antibiotic Resistance and nalB Mutants in Pseudomonas aeruginosa Isolated from Burnt Patients of Shohada Mehrab Yazd Hospital Burn Ward,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 9, no. 2, pp. 140–146, 2020, [Online]. Available: https://sid.ir/paper/988515/en

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