Detection of IL-10 gene polymorphisms in patients with ulcerative colitis in Northern Iran

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Naemi Mahsa; ZAHMATKESH ROODSARI RASOUL

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Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2019 | Volume:29 | Issue:2 Page(s): 141-149

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Title

Detection of IL-10 gene polymorphisms in patients with ulcerative colitis in Northern Iran

Author(s)

Naemi Mahsa | ZAHMATKESH ROODSARI RASOUL | Issue Writer Certificate

Keywords

Ulcerative colitisQ3

PolymorphismQ2

IL-10 (A1082G)Q1

IL-10 (T819C)Q1

Abstract

Background: Ulcerative colitis is a multifactorial disease in which the environmental and genetics factor are being involved together. Interleukins are a group of cytokine which are produced through T cells, monocytes, macrophages, and endothelial cells. Interleukin-10 is an important multitasking cytokine that has a key role in inflammatory responses. The promoter of interlekin-10 is highly polymorphic and many of its Polymorphisms were identified. The purpose of this study was to investigate and detect the A1082G and T819C Polymorphisms of interleukin-10 promoter in Ulcerative colitis patients. Materials and methods: In this case-control study, DNA from 150 individuals with Ulcerative colitis and 150 controls were determined by PCR technique. Data were analyzed by Chi-square test using SPSS software. Also, odds ratios and 95% confidence interval were calculated. Results: The results showed that distribution of GG and CC genotypes and frequency of G and C alleles (related to A1082C and T819C Polymorphisms, respectively) was significantly different between patient and control groups. Conclusion: According to the results, both Polymorphisms of IL-10 gene promoter (A1082G and T819C), including G allel and C allel, respectively, are likely to be considered as risk factors for Ulcerative colitis. Moreover, both genotype of GG and CC can increase the incidence of Ulcerative colitis.

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APA: Copy

Naemi, Mahsa, & ZAHMATKESH ROODSARI, RASOUL. (2019). Detection of IL-10 gene polymorphisms in patients with ulcerative colitis in Northern Iran. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 29(2 ), 141-149. SID. https://sid.ir/paper/98929/en

Vancouver: Copy

Naemi Mahsa, ZAHMATKESH ROODSARI RASOUL. Detection of IL-10 gene polymorphisms in patients with ulcerative colitis in Northern Iran. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2019;29(2 ):141-149. Available from: https://sid.ir/paper/98929/en

IEEE: Copy

Mahsa Naemi, and RASOUL ZAHMATKESH ROODSARI, “Detection of IL-10 gene polymorphisms in patients with ulcerative colitis in Northern Iran,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 29, no. 2 , pp. 141–149, 2019, [Online]. Available: https://sid.ir/paper/98929/en

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