Uncoupling Protein 2 Expression Modulates Obesity in Chronic Kidney Disease Patients

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Shawky Salma Ahmed; Gaber Osama; Mostafa Ezzat; Sarhan Walaa Mohamed

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Paper Information

Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2021 | Volume:10 | Issue:1 Page(s): 105-118

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Information Journal Paper

Title

Uncoupling Protein 2 Expression Modulates Obesity in Chronic Kidney Disease Patients

Author(s)

Shawky Salma Ahmed | Gaber Osama | Mostafa Ezzat | Sarhan Walaa Mohamed | Issue Writer Certificate

Keywords

Chronic Kidney Disease (CKD)

Obesity

Uncoupling Protein 2 (UCP2) Gene Expression

Real-Time Polymerase Chain Reaction (RT-PCR)

Abstract

Background: Obesity is a multifactorial metabolic disease resulting from behavioral and genetic factors. Obesity is linked to diabetes mellitus and hypertension, which are considered as major risk factors for chronic kidney disease (CKD),moreover, it has a direct effect on developing CKD and end stage renal disease (ESRD). Here was aimed to examine the association between uncoupling protein 2 (UCP2) gene expression and Obesity in CKD patients. Methods: UCP2 gene expression was analyzed by real time polymerase chain reaction (RT-PCR) in 93 participants divided into three groups. The groups included 31 non-obese CKD patients, 31 obese CKD patients, and 31 healthy, age-matched, unrelated volunteers as a control group. Results: UCP2 gene expression was significantly relevant when comparing the non-obese CKD and obese CKD groups to the control group (p< 0. 001). No significant association was found when the groups were compared by gender,Chi-square (X2) was 2. 38 and p= 0. 304. A significant negative correlation was found between UCP2 gene expression and BMI in CKD (p< 0. 05). Conclusions: These results indicate that UCP2 gene expression plays a significant role as a risk factor for Obesity in CKD patients.

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APA: Copy

Shawky, Salma Ahmed, Gaber, Osama, Mostafa, Ezzat, & Sarhan, Walaa Mohamed. (2021). Uncoupling Protein 2 Expression Modulates Obesity in Chronic Kidney Disease Patients. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 10(1), 105-118. SID. https://sid.ir/paper/989429/en

Vancouver: Copy

Shawky Salma Ahmed, Gaber Osama, Mostafa Ezzat, Sarhan Walaa Mohamed. Uncoupling Protein 2 Expression Modulates Obesity in Chronic Kidney Disease Patients. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2021;10(1):105-118. Available from: https://sid.ir/paper/989429/en

IEEE: Copy

Salma Ahmed Shawky, Osama Gaber, Ezzat Mostafa, and Walaa Mohamed Sarhan, “Uncoupling Protein 2 Expression Modulates Obesity in Chronic Kidney Disease Patients,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 10, no. 1, pp. 105–118, 2021, [Online]. Available: https://sid.ir/paper/989429/en

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