مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

37
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

40
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Atractylodes chinensis volatile oil up-regulated IGF-1 to improve diabetic gastroparesis in rats

Pages

  520-526

Abstract

 Objective(s): Diabetic Gastroparesis (DGP) is one of the main complications of diabetes, and more than half of diabetes cases are accompanied by Gastroparesis. This study aims to explore the effect of Atractylodes chinensis volatile oil (ACVO) on DGP rats. Materials and Methods: The rats were injected with STZ combined with a high-sugar and high-fat diet in an irregular manner to establish the DGP model. ACVO at different doses (9. 11 mg/kg, 18. 23 mg/kg, and 36. 45 mg/kg) were given by intragastric administration. A mixture of cisapride and metformin was used as the positive control. At the end of the experiment, gastric emptying and intestinal propulsion were determined. Then the tissue samples and blood were taken from each group for serum analysis, western blot and immunopathological examination. Results: After treatment with ACVO, body weight increased and blood glucose decreased when compared with rats in the DGP group. Gastric emptying and intestinal propulsion were accelerated, and gastric acid secretion increased. The serum Insulin-like growth factor-1 (IGF-1) level was increased. Protein expressions and positive cells of IGF-1 receptor (IGF-1R), acetylcholine transferase (CHAT), and Stem cell factors (SCF) in the stomach were significantly increased determined by western blot and immunofluorescence staining. The morphology and the number of Interstitial cells of cajal (ICCs) in the stomach were restored, determined by hematoxylin and eosin staining and immunohistochemical staining, respectively. Conclusion: ACVO effectively alleviated DGP in rats, and its mechanism may be related to the up-regulation of IGF-1/IGF-1R signaling.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Li, Hongzeng, Wang, Yitong, Tian, Yuxin, Tian, Feiyue, Xing, Zhiyang, Wang, Yunfei, Yan, Meixing, & Gong, Yanling. (2022). Atractylodes chinensis volatile oil up-regulated IGF-1 to improve diabetic gastroparesis in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 25(4), 520-526. SID. https://sid.ir/paper/991174/en

    Vancouver: Copy

    Li Hongzeng, Wang Yitong, Tian Yuxin, Tian Feiyue, Xing Zhiyang, Wang Yunfei, Yan Meixing, Gong Yanling. Atractylodes chinensis volatile oil up-regulated IGF-1 to improve diabetic gastroparesis in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2022;25(4):520-526. Available from: https://sid.ir/paper/991174/en

    IEEE: Copy

    Hongzeng Li, Yitong Wang, Yuxin Tian, Feiyue Tian, Zhiyang Xing, Yunfei Wang, Meixing Yan, and Yanling Gong, “Atractylodes chinensis volatile oil up-regulated IGF-1 to improve diabetic gastroparesis in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 25, no. 4, pp. 520–526, 2022, [Online]. Available: https://sid.ir/paper/991174/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button