SIMVASTATIN-INDUCED RENAL PROTECTION AGAINST ISCHEMIA-REPERFUSION INJURY MEDIATED BY ACTIVATION OF ATP-SENSITIVE POTASSIUM CHANNELS

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ABOTALEB N.; PAZOUKI H.R.; HOMAYOONFAR H.; NOURI SAMAGH J.

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Journal: Razi Journal of Medical Sciences Year:2010 | Volume:17 | Issue:71 Page(s): 7-13

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Title

SIMVASTATIN-INDUCED RENAL PROTECTION AGAINST ISCHEMIA-REPERFUSION INJURY MEDIATED BY ACTIVATION OF ATP-SENSITIVE POTASSIUM CHANNELS

Author(s)

ABOTALEB N. | PAZOUKI H.R. | HOMAYOONFAR H. | NOURI SAMAGH J. | Issue Writer Certificate

Keywords

ISCHEMIA-REPERFUSIONQ3

ATP-SENSITIVE POTASSIUM CHANNELQ3

SIMVASTATINQ3

KIDNEYQ2

Abstract

Background & Aim: Renal dysfunction due to ISCHEMIA-REPERFUSION (I/R) injury is a common problem following renovascular surgery or KIDNEY transplantation. There is a lot of emerging evidence that statins, which are HMG-COA reductase inhibitors, have renal protective effects against ISCHEMIA-REPERFUSION injury, but the exact mechanism of their protective effect has not been detected properly. This study examined whether SIMVASTATIN reduces I/R injury in KIDNEY. In addition, we investigated whether the observed renal protective effect of SIMVASTATIN is due to the activation of ATP-sensitive potassium (KATP) channels by using selective antagonist glibenclamide. Material and Method: In this experimental study, male wistar rats(150-200 g) were randomized into five groups while their right KIDNEYs had been removed 3 weeks prior to the study: sham operated, I/R group, I/R pretreated with SIMVASTATIN (20mg/kg/day) for 3 days by gavage, SIMVASTATIN + glibenclamide(0.3mg/kg ip) +I/R and glibenclamide +I/R. The I/R injury was induced by clamping the left renal artery for 45 minutes followed by reperfusion for 2 hours. For statistical comparison,one-way ANOVA, Mann-Whitney test and Tukey were used and p<0.05 and p<0.01 were considered significant. Results: In I/R group, the level of both BUN and creatinin, as indices of renal cell damage, were significantly increased compared with the sham-operated group. However, these increases were significantly inhibited by the treatment with SIMVASTATIN. SIMVASTATIN also improved the renal histological damage compared with the IR group (p<0.05). Glibenclamide, the KATP channel inhibitor, significantly decreased the protective effect of SIMVASTATIN (p<0.01).Conclusion: SIMVASTATIN, as an HMG-COA reductase inhibitor, has renal protective effects against ISCHEMIA-REPERFUSION injury independent of its lipid–lowering properties.This protective effect is mediated via activation of the adenosine triphosphate-sensitive potassium channels, and glibenclamide as a KATP channel inhibitor reduces this benefical effect of SIMVASTATIN.

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APA: Copy

ABOTALEB, N., PAZOUKI, H.R., HOMAYOONFAR, H., & NOURI SAMAGH, J.. (2010). SIMVASTATIN-INDUCED RENAL PROTECTION AGAINST ISCHEMIA-REPERFUSION INJURY MEDIATED BY ACTIVATION OF ATP-SENSITIVE POTASSIUM CHANNELS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 17(71), 7-13. SID. https://sid.ir/paper/9922/en

Vancouver: Copy

ABOTALEB N., PAZOUKI H.R., HOMAYOONFAR H., NOURI SAMAGH J.. SIMVASTATIN-INDUCED RENAL PROTECTION AGAINST ISCHEMIA-REPERFUSION INJURY MEDIATED BY ACTIVATION OF ATP-SENSITIVE POTASSIUM CHANNELS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2010;17(71):7-13. Available from: https://sid.ir/paper/9922/en

IEEE: Copy

N. ABOTALEB, H.R. PAZOUKI, H. HOMAYOONFAR, and J. NOURI SAMAGH, “SIMVASTATIN-INDUCED RENAL PROTECTION AGAINST ISCHEMIA-REPERFUSION INJURY MEDIATED BY ACTIVATION OF ATP-SENSITIVE POTASSIUM CHANNELS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 17, no. 71, pp. 7–13, 2010, [Online]. Available: https://sid.ir/paper/9922/en

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