The idea of modernism and the trend for it to be continued, particularly its focus on technological tools in various fields such as architecture, has led to a dozen of crises in the second half of the last century. These crises are almost environmental, although the challenges arising from modern life in modern buildings have been discussed by architects and designers. In this regard, sustainable development was born to maintain the current capabilities without devastating results for the future generation. Since the 1990s, sustainable architecture has been considered in many constructions. On the other hand, the lack of human contact with nature, due to their constant presence in buildings and its consequences as a weakness for modernism, has caused presented different solutions in the shape of various new thinking that, biophilic architecture is one of which. Biophilic architecture refers to the biophilia hypothesis first defined by biologist Edward Wilson in 1984, although it came to other fields such as architecture and design. This kind of architecture, which has been less than 30 years, fills the gap between humans and nature. In addition, it wishes to follow the natural patterns inspired by the natural shapes of fauna and flora in designing a building to improve the integration of artificial structures into nature. However, the role of biophilic architecture in meeting sustainability requirements has yet to be considered. So, the main goal of this study is to investigate the relationship between sustainability and biophilic architecture. In other words, this research plans to understand the effective factors of biophilic architecture in fulfilling sustainability goals. The method of this paper is descriptive–, analytical, and the way for data collection is documental. As this study is just theoretical, it includes theoretical perspectives and would be a review research. The results of this theoretical study show that the biophilic architecture approach is a part of sustainable architecture. This approach has the potential to offer and suggest sustainability benefits. Biophilic architecture has a wide range of factors, the same as sustainability. They include social, environmental/ecological, psychological, economic, physical, and even management aspects on the building scale. Some of the most important factors which have been understood in this study are Affordability of housing, reduce air pollution and optimize air quality, Reduce stress, Raise environmental awareness, Improve water management (stormwater management, water recycling, and water runoff quality), Increase worker productivity, Reduce energy consumption, Improve biodiversity, equal access to public facilities in the building, heat comfort, well-being, natural light, natural materials, natural landscape and vegetation, green technology, green materials, improve education quality, safety, crime, risk, adaptability, green space, land, food, transport, planning, policies, and community. In the end, this study suggests that researchers investigate and measure these factors' impact on buildings with a focus on local characteristics and introduce related criteria and indicators.