The present study has reviewed the characteristics of some 170 inter-basin water transfer projects in various parts of the world with different ecological conditions. The minute reviewing of existing experiences indicated that the apogee of implementing inter-basin water transfer projects has been met in the 19th century. According to the results, 43.75, 18.75, 12.5 and 25 percent of the projects have been respectively implemented for drinking and agricultural water supply, energy production, environmental objectives, and multi-purpose water supply purposes. However, in many developed countries more than 80 percent of the inter-basin water transfer projects were implemented for providing drinking water. According to the data, more than 27 percent of the global water withdrawal capacity is transferred with inter-basin water transfer projects. In Iran, based on available data, the capacity of inter-basin water transfer is 6.35 km3 per annum mainly transferred for agricultural purposes through constructing long tunnels. Since inter-basin water transfer projects directly affected the management of origin and destination basins, the socioeconomic and environmental conditions were often weakened in one of the basins in the long term. Consequently, inter-basin water transfer projects should be applied only in emergency conditions when no other alternative solution is practicable and when emergency drinking water supply is emerged. This should also satisfy the integrated recognition of study region conditions and its potentials, having comprehensive and systematic management approach and ultimately with consideration of environmental, economic, social and political dimensions.