Background and Objective: Relations between parents and children are one of the most influential factors in a person’ s life, affecting the development of functions, features, and shaping the harms. The present study aims at examining the relationship of parent-child relationship pattern based on Iranian-Islamic native model with communication skills and students’ self-esteem intermediation. Methodology: to this end, a sample population consisting of 400 students of Jahrom University was selected through stratified sampling method. The required data were obtained using Baqeri’ s questionnaire for models of parent-child relationship (2013), communication skills test (Queendom, 2004), and self-esteem inventory (Cooper Smith, 1967). In order to investigate the relationship between variables, multiple regression analysis was used. Results: The findings showed that the the subscales of ‘ inflexibility’ , ‘ instability’ , and ‘ indifference’ in father-child relationship model and the subscales of ‘ acceptance’ , and ‘ entanglement’ in mother-child relationship model affect the communication skills significantly. Similarly, the results showed that the subscales of ‘ acceptance’ in father-child relationship model and the subscales of ‘ acceptance’ and ‘ entanglement’ in mother-child relationships model affect self-esteem significantly. In addition, the subscale of social self-esteem had a significant effect on students’ communication skills. Conclusion: Considering the results, the dominant pattern of relations between parents and children is security-centered and freedom-centered, which in some way damages the children’ s value system and their beliefs, and they will always be in danger of being absorbed by individuals, groups, sects, spying agencies, etc., who will determine their direction and obligations.