Background: Fatigue is one of the common complaints of women in pregnancy. Physical, emotional and situational factors are involved. Gestational fatigue with %72 prevalence in moderate and severe cases significantly affects on maternal morbidity.Purpose: This descriptive-correlational study was conducted to determine the intensity of fatigue and its related factors in pregnant women referring to Urban Health Centers affiliated to Isfahan University of Medical Sciences in 2006.Methods: Subjects included 180 women after 32ndweek of their pregnancy selected by multistage sampling method. A questionnaire for fatigue was used to collect data with a scoring range between 0 and 60. The scores were then classified into mild, moderate and severe groups. Finally, the related factors and their correlation were assessed.Results: Findings showed that mean age of the subjects was 26.±4.7 marital age was 20.6±4 and gravidity was 2.4±1.3%. 37.7, %35, and %27.2 of women experienced mild, moderate, and sever fatigue respectively. There was a significant relation between fatigue intensity and number of family members, rest level, gravidity, parity, interval between previous pregnancy and the present one, facing with tiring factors, household affairs, and weight gain during pregnancy. No significant relation was found between fatigue and education, planned pregnancy and age.Conclusion: With respect to high rate of moderate and sever fatigue in pregnancy, including the instruction of relaxation techniques in prenatal care is recommended.